江苏省疑似脊髓灰质炎疫苗病毒变异株循环疫情的流行病学调查

发布时间：2018-03-30 09:03

  本文选题：急性弛缓性麻痹　切入点：疫苗变异脊髓灰质炎病毒　出处：《现代预防医学》2014年04期

【摘要】：目的分析一起疑似脊灰疫苗变异株病毒循环调查处置过程。方法进行病例核实诊断和个案调查,开展医院AFP病例主动搜索,评价AFP病例监测系统运转情况,调查密切接触者儿童粪便带毒率及脊灰疫苗接种率。结果在3例病例粪便标本中同时分离到Ⅲ型脊灰病毒,该病毒VP1区与Sabin疫苗株病毒相比,分别有0.44%、0.55%和0.44%的核苷酸变异。3例病例发病地点相距较远,均接种口服脊灰减毒活疫苗(OPV),密切接触者粪便标本未分离到脊灰病毒,当地儿童常规免疫接种率均处较高水平。结论脊灰疫苗变异株病毒未在当地发生循环。提高AFP监测系统敏感性、脊灰疫苗接种率和疫情应急能力,是有效阻止脊灰疫苗病毒变异株循环和脊灰野病毒输入的有效措施。
[Abstract]:Objective to analyze the process of virus cycle investigation and disposal of a suspected poliomyelitis vaccine variant strain.Methods the case verification diagnosis and case investigation were carried out, and the active search of hospital AFP cases was carried out to evaluate the operation of the AFP case monitoring system, and to investigate the fecal infection rate and poliomyelitis vaccination rate of children in close contact.Results poliovirus type 鈪，

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