广东省2013年乙型病毒性肝炎高流行区农村育龄妇女血清流行病学调查

发布时间：2018-04-05 22:16

本文选题：育龄妇女　切入点：血清流行病学调查　出处：《中国疫苗和免疫》2015年04期

【摘要】：目的了解广东省2013年乙型病毒性肝炎(乙肝)高流行区农村育龄妇女乙肝病毒(Hepatitis B Virus,HBV)感染现状,评估乙肝疫苗(Hepatitis B Vaccine,Hep B)接种效果,为完善HBV母婴阻断策略提供参考。方法2013年采用分层随机抽样在广东省乙肝高流行区3个县(市,下同)农村抽取15~49岁育龄妇女进行乙肝血清流行病学调查。用酶联免疫吸附试验检测乙肝血清学标志物,调查人口学特征、肝炎病史、Hep B接种史等。结果共调查育龄妇女2076人,平均年龄30.64岁。3个调查县育龄妇女乙肝病毒表面抗原(HBV Surface Antigen,HBs Ag)、抗乙肝病毒表面抗原抗体(Antibody to HBs Ag,Anti-HBs)、抗乙肝病毒核心抗原抗体(Antibody to HBV Core Antigen,Anti-HBc)年龄标化阳性率分别为12.81%、63.73%、65.90%。HBs Ag阳性妇女中乙肝病毒e抗原(HBV e Antigen,HBe Ag)和抗乙肝病毒e抗原抗体(Antibody to HBe Ag,Anti-HBe)阳性率分别为29.76%和63.94%。不同年龄组育龄妇女HBs Ag、Anti-HBc、HBe Ag和Anti-HBe阳性率差异有统计学意义(χ2HBs Ag=42.01,χ2Anti-HBc=443.35;χ2HBe Ag=38.10,χ2Anti-HBe=36.51;P均0.01),但Anti-HBs阳性率差异无统计学意义(χ2Anti-HBs=5.41,P=0.14)。不同地区、职业育龄妇女HBs Ag、Anti-HBs、Anti-HBc阳性率差异均有统计学意义(地区间比较:χ2HBs Ag=9.07,χ2Anti-HBs=7.04,χ2Anti-HBc=39.44;P均0.01;职业间比较:χ2HBs Ag=46.17,χ2Anti-HBs=13.30,χ2Anti-HBc=445.18;P均0.05)。育龄妇女Hep B接种率为31.22%,有Hep B接种史组Anti-HBs阳性率(71.87%)高于无Hep B接种史组(58.57%)和Hep B接种史不详组(63.73%)。结论广东省2013年乙肝高流行区农村育龄妇女HBs Ag携带率处于较高水平,小年龄组育龄妇女HBs Ag携带率下降明显,Hep B接种预防效果显著,仍需继续落实HBV母婴阻断干预措施。
[Abstract]:Objective to investigate the status of hepatitis B virus (HBV) infection among women of childbearing age in rural areas of high prevalence area of hepatitis B in Guangdong province in 2013, and to evaluate the effect of hepatitis B vaccine against hepatitis B vaccine in order to provide reference for improving the strategy of blocking HBV mother and child.Methods stratified random sampling was used in 3 counties (cities, the same below) in Guangdong province in 2013 to carry out seroepidemiological survey of hepatitis B among 1549 years old women of childbearing age.Enzyme linked immunosorbent assay (Elisa) was used to detect the serological markers of hepatitis B, to investigate the demographic characteristics, and to investigate the history of Hepatitis B vaccination.Results A total of 2076 women of childbearing age were investigated.The positive rates of hepatitis B virus e antigens (HBe) and anti HBe antigens (anti body to HBe anti HBeAg) were 29.76% and 63.94%, respectively.
【作者单位】：广东省疾病预防控制中心;中国疾病预防控制中心免疫规划中心;
【基金】：国家科学技术艾滋病和病毒性肝炎等重大传染病防治重大专项乙型肝炎病毒免疫预防新策略研究(编号2012ZX10002001)
【分类号】：R512.62;R181.3

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