长春市中老年人群代谢综合征流行病学调查

发布时间：2018-04-09 09:19

本文选题：代谢综合征　切入点：2型糖尿病　出处：《吉林大学》2007年硕士论文

【摘要】： 代谢综合征是一种以代谢紊乱为特征的征候群,并已作为2型糖尿病及心血管疾病的独立预测因素正越来越受到广泛关注。代谢综合征主要包括中心性肥胖、糖耐量异常、血脂代谢紊乱等危险因素,代谢综合征患者糖尿病、心血管疾病的发病率约是正常人群的5倍,严重危害人类的身心健康。 1988年Reaven首先提出代谢综合征的理论,又称为胰岛素抵抗学说,其核心内容是由于机体存在胰岛素降糖作用方面生物学效应降低,而其脂代谢、电解质代谢作用正常。机体为代偿胰岛素选择性生物作用的异常,首先维持糖代谢的平衡,导致高胰岛素血症,而这种继发性高胰岛素血症可导致机体脂代谢、离子等代谢异常。因此胰岛素抵抗及代偿性高胰岛素血症导致机体各种基本营养物质代谢紊乱,出现高血压、肥胖、血脂紊乱、糖尿病、动脉硬化等临床症状,对整个人类健康构成严重威胁。代谢综合征的发生有一定遗传因素,但更重要的是生活方式改变造成的恶果。大量流行病学研究证明随着各国和各类社会群体富裕程度、生活方式的不同,代谢综合征相关疾病发生率相差悬殊。因此,了解代谢综合征患病情况,并根据地区和不同人群特点进行防治,尤为重要。本文对在2005年5月到7月791例在我院年度体检的吉林省离退休及在职副厅级以上干部进行了代谢综合征的流行病学调查,了解在该人群中代谢综合征发生情况。本组资料显示:在791例中老年体检对象中,MS的总患病率为20.1%,整个人群的肥胖/超重占45.3%,高血压为47.41%,2型糖尿病和糖代谢异常总发生率为28.44%,高甘油三酯血症为47.28%。2型糖尿病、糖代谢异常和高血压随增龄逐步增加,而高甘油三酯血症和肥胖的发生率则逐步下降。本研究显示调查人群中代谢综合征发生率明显高于全国平均水平,揭示该人群应积极调整生活方式、降低有关疾病的发生、发展,提高生活质量。
[Abstract]:Metabolic syndrome is a syndrome characterized by metabolic disorder, and has been widely concerned as an independent predictor of type 2 diabetes and cardiovascular disease.Metabolic syndrome mainly includes central obesity, abnormal glucose tolerance, dyslipidemia and other risk factors. The incidence of diabetes mellitus and cardiovascular disease in patients with metabolic syndrome is about 5 times as high as that in normal people, which seriously endangers the physical and mental health of human beings.In 1988, Reaven first put forward the theory of metabolic syndrome, also known as insulin resistance theory. The core content of the theory is that the biological effect of insulin hypoglycemia is reduced, but its lipid metabolism and electrolyte metabolism are normal.For the abnormality of selective biological action of compensatory insulin, the first step is to maintain the balance of glucose metabolism, which leads to hyperinsulinemia, and this secondary hyperinsulinemia can lead to abnormal metabolism of lipid and ions.Therefore, insulin resistance and compensatory hyperinsulinemia lead to metabolic disorders of various basic nutrients, hypertension, obesity, dyslipidemia, diabetes, arteriosclerosis and other clinical symptoms, which pose a serious threat to human health.Metabolic syndrome has some genetic factors, but more important is the negative consequences of lifestyle changes.A large number of epidemiological studies have proved that the incidence of metabolic syndrome-related diseases varies greatly with the wealth and lifestyle of different countries and social groups.Therefore, it is important to understand the prevalence of metabolic syndrome and to prevent and cure metabolic syndrome according to regional and different population characteristics.An epidemiological survey of metabolic syndrome was carried out in 791 cases of retired cadres in Jilin Province from May to July 2005, and the incidence of metabolic syndrome in this population was investigated.The incidence of hypertriglyceridemia and obesity decreased with age.This study shows that the incidence of metabolic syndrome in the survey population is significantly higher than the national average. It is revealed that the population should actively adjust their lifestyle, reduce the incidence of related diseases, develop and improve the quality of life.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2007
【分类号】：R589;R181.3

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