一种聚六亚甲基单胍中和剂的发现及鉴定实验研究

发布时间：2018-04-11 07:10

本文选题：中和剂 + 聚乙烯基硫酸钾　；参考：《中国消毒学杂志》2014年06期

【摘要】：目的研究鉴定一种可化学显色的聚六亚甲基单胍盐中和剂。方法采用胶体滴定法建立聚六亚甲基单胍与聚乙烯基硫酸钾发生反应的直线回归方程,并在试管中用化学指示液指示聚六亚甲基单胍与中和剂中和完全的终点,同时用悬液定量杀菌试验方法对该中和剂进行鉴定实验。结果甲苯胺蓝指示聚乙烯基硫酸钾中和聚六亚甲基单胍完全的终点明确,聚六亚甲基单胍与0.0025 mol/L聚乙烯基硫酸钾进行等量反应的线性范围为1.5~4.0 mg,线性相关系数为0.9999。经悬液定量杀菌试验法鉴定证明,聚乙烯基硫酸钾能有效中和聚六亚甲基单胍的杀菌作用,且中和剂和中和产物溶液对微生物的生长没有影响。结论 0.0025 mol/L的聚乙烯基硫酸钾可有效中和4.8 g/L以下浓度的聚六亚甲基单胍盐的杀菌效果,并能通过指示液化学显色指示中和反应的终点。
[Abstract]:Objective to study and identify a chemically colored polyhexamethylene monoguanidine salt neutralizer.Methods the linear regression equation of the reaction between polyhexamethylene monoguanidine and polyvinyl potassium sulfate was established by colloidal titration, and the complete end point of neutralization between polyhexamethylene monoguanidine and neutralizer was indicated by chemical indicator in test tube.Meanwhile, suspension quantitative germicidal test was used to identify the neutralizer.Results toluidine blue indicated that the complete end point of polyhexamethylene monoguanidine neutralization was clear. The linear range of the equal reaction between polyhexamethylene monoguanidine and 0.0025 mol/L polyethylene potassium sulfate was 1.5mg and the linear correlation coefficient was 0.999999.The suspension quantitative germicidal test confirmed that polythylene potassium sulfate could neutralize the bactericidal effect of polyhexamethylene monoguanidine, and neutralizer and neutralization product solution had no effect on the growth of microorganism.Conclusion 0.0025 mol/L polythylated potassium sulfate can effectively neutralize the bactericidal efficacy of polyhexamethylene monoguanidine salt with concentration below 4.8 g / L, and can indicate the end point of the neutralization reaction by chemical coloration of indicator solution.
【作者单位】：军事医学科学院疾病预防控制所;
【基金】：北京市科技新星计划资助项目(Z131102000413069) 军事医学科学院创新基金项目资助(2012CXJJ035)
【分类号】：R187

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