2010-2015年河北省哨点医院腹泻患儿杯状病毒感染状况调查及流行特征分析

发布时间：2018-04-14 23:02

  本文选题：病毒性腹泻 + 杯状病毒　； 参考：《中国病原生物学杂志》2017年12期

【摘要】：目的了解河北地区近年来5岁及以下腹泻患儿人类杯状病毒(HuCV)感染状况及流行病学特征。方法2010-2015年收集2 211份河北省哨点医院5岁及以下腹泻患儿粪便标本,采用多重RT-PCR检测HuCV感染情况并进行分型(诺如GⅠ、诺如GⅡ或札如病毒),同时收集患儿流行病学资料进行分析。结果 2 211份粪便标本HuCV总检出率为19.27%(426/2211),各年份检出率差异有统计学意义(χ~2=48.680,P0.01),呈现两年一个高峰的波动趋势。感染者以12~17月龄占多数,2岁以下患儿占总病例数的89.91%(383/426);城市患儿HuCV检出率高于农村(χ~2=4.222,P0.05),但性别间检出率差异无统计学意义(χ~2=3.467,P0.05)。每年的11月至次年4月为HuCV感染高峰期,病例数占全年总病例数的76.29%(325/426)。全年呈现3个HuCV检出高峰(3月、7月和10月),不同月份病毒检出率差异有统计学意义(χ~2=36.609,P0.01)。检出的HuCV以NoV为主(87.32%),其中单一GⅠ感染占12.10%(45/372),单一GⅡ感染占87.90%(327/372)。另有混合感染4例。结论 HuCV为河北地区5岁以下尤其是2岁以下腹泻患儿重要病原体之一,GⅡ型为优势流行株,HuCV感染高峰集中在秋冬季节,但仍需严防夏季暴发流行。
[Abstract]:Objective to investigate the prevalence and epidemiological characteristics of human calix virus HuCVV infection in children aged 5 years and under in Hebei province.Methods from 2010 to 2015, 2 211 fecal specimens of children aged 5 years and under in sentinel hospital of Hebei Province were collected. Multiple RT-PCR was used to detect the infection of HuCV.At the same time, the epidemiological data of children were collected and analyzed.Results the total detection rate of HuCV in 2 211 fecal specimens was 19.27% (426 / 2211), and the difference was statistically significant in each year (蠂 ~ (2 / 2) = 48.680 / (P0.01)), which showed a fluctuation trend of a peak in two years.The prevalence rate of HuCV in urban children was higher than that in rural areas (蠂 ~ (2 / 2) 4.222) (P 0.05), but there was no significant difference between sexes (蠂 ~ (2 / 2) 3.467) (P 0.05).From November to April each year, HuCV infection peaks, accounting for 76.29% of the total number of cases in the year.In the whole year, there were three peaks of HuCV detection (March, July and October), and there were significant differences in the detection rate of virus in different months (蠂 ~ (2 +) ~ (36.609)) (P ~ (0.01)).The main HuCV detected was NoV 87.32, in which single G 鈪，

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