广东严重急性呼吸综合征突发事件流行病学研究

发布时间：2018-04-24 05:13

本文选题：流行病学 + 严重急性呼吸综合征(SARS)　；参考：《第一军医大学》2006年博士论文

【摘要】：突发事件严重急性呼吸综合征(SARS)的流行必须具备三个因素，即传染源、传播途径和人群易感性；而导致SARS感染发生也必须具备三个要素，即病因(病原体)、宿主和环境。本项目采用流行病学方法，对广东地区SARS病原体、感染宿主和它们所处的环境进行研究；研究工作由3部分组成，即流行特征、检测方法比较和影响因素分析。现根据目的、方法、结果和讨论分别介绍如下。目的 (1) 根据广东地区2002年11月至2003年5月临床诊断SARS病例，，筛检实验诊断SARS病例；分析其实验诊断SARS病例流行病学特征，描述SARS流行的时间分布、地点分布和人群分布，并计算其危险因素的比值比(OR)和95％可信区间(CI)等。 (2) 比较目前各种SARS的检测方法，分析各种检测方法的差异和优劣，并结合临床SARS特征以期归纳出最佳的实验诊断策略。 (3) 探索三个影响因素： ①气候因素：探索广东地区SARS发病与各种气候因素的关系，为从环境角度预防和控制SARS提供科学依据。 ②毒株因素：通过对SARS CoV毒株基因序列的变异分析，揭示SARS-CoV毒株出现和流行与基因进化的关系，为从病原学角度预防和控制SARS提供科学依据。 ③患者因素：通过SARS患者危险因素分析，为从患者角度更好地和有效地
[Abstract]:The epidemic of severe acute respiratory syndrome (SARS) must have three factors, namely, the source of infection, the route of transmission and the susceptibility of the population, and the cause of SARS infection must also have three factors, namely, etiology (pathogen, host and environment). In this project, epidemiological methods were used to study SARS pathogens, infected hosts and their environment in Guangdong, and the research work was composed of three parts, namely, epidemic characteristics, comparison of detection methods and analysis of influencing factors. According to the purpose, method, results and discussion are introduced as follows. Purpose 1) according to the clinical diagnosis of SARS cases in Guangdong from November 2002 to May 2003, screening the SARS cases, analyzing the epidemiological characteristics of SARS cases, describing the time distribution, location distribution and population distribution of SARS epidemic. The ratio of risk factors to OR and 95% CI were calculated. 2) compare the current detection methods of SARS, analyze the differences and advantages of each detection method, and combine the clinical SARS characteristics to conclude the best experimental diagnosis strategy. 3) to explore three influencing factors: 1 Climate factors: to explore the relationship between the incidence of SARS and various climatic factors in Guangdong, to provide scientific basis for the prevention and control of SARS from the environmental point of view. 2 strain factors: by analyzing the variation of gene sequence of SARS CoV strain, the relationship between the emergence and prevalence of SARS-CoV strain and gene evolution was revealed, which provided a scientific basis for the prevention and control of SARS from the point of view of etiology. 3 patient factors: by analyzing the risk factors of patients with SARS, we can make a better and more effective approach from the patient's point of view.
【学位授予单位】：第一军医大学
【学位级别】：博士
【学位授予年份】：2006
【分类号】：R181.3

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