甘肃省武威市幽门螺杆菌感染流行病学调查

发布时间：2018-04-27 10:29

  本文选题：幽门螺杆菌 + 流行病学　； 参考：《兰州大学》2009年硕士论文

【摘要】： 目的了解胃癌高发地区甘肃省武威市成人、儿童和青少年幽门螺杆菌(H pylori,Hp)的感染情况,并对Hp感染相关因素进行分析,为本地区防治幽门螺杆菌提供科学依据。 方法于2007年10月至2008年5月对武威市不同人群进行Hp感染情况调查。(1)采用酶联免疫吸附试验(ELISA)检测法对武威市城乡居民中随机抽取797例成人开展Hp感染率及相关因素的横断面研究。(2)采用幽门螺杆菌抗原检测法对武威市938名3～18岁儿童或青少年和96户家庭进行Hp粪便抗原检测,并作Hp感染相关因素分析。(3)采用幽门螺杆菌免疫印迹法对经Hp粪便抗原检测阳性的80名儿童或青少年进行Hp毒力蛋白分析。所有调查均采用标准化问卷收集研究对象的个人疾病史、家族疾病史、危险因素、保护因素等信息。 结果(1)武威市成人Hp感染率为81.8%,且随着年龄的增加有增加的趋势。x~2检验分析结果提示,Hp感染可能与年龄、职业、文化水平、饮水来源等因素有关。多因素logistic回归分析提示,职业、饮水来源、饭前洗手情况以及家中有胃癌或胃部疾病患者是Hp感染的危险因素。(2)武威市儿童及青少年Hp总感染率72.3%,各年龄组比较无统计学意义。x~2检验分析结果提示,Hp感染可能与居住地区、父母职业、饮水来源、是否上过幼儿园、是否生吃蔬菜、是否刷牙及母乳喂养有关。多因素logistic回归分析提示,饮水来源、上过幼儿园、生吃蔬菜是Hp感染的危险因素。(3)Hp阳性标引者家中其他成员Hp感染率(82.3%)显著高于Hp阴性标引者家中其他成员Hp感染率(47.4%),两者差异有统计学意义(x~2=19.736 P＜0.05)。(4)根据临床分型:Ⅰ型Hp感染57例(71.3%)Ⅱ型Hp感染23例(28.7%)。结论(1)武威市成人、儿童和青少年具有较高的Hp感染率,Hp感染可能存在人-人传播和水源传播途径。(2)Hp感染存在家庭聚集现象。(3)武威市儿童及青少年Hp感染以Ⅰ型感染为主。
[Abstract]:Objective to investigate the prevalence of Helicobacter pylori (HP) infection in adults, children and adolescents in Wuwei City, Gansu Province, and to analyze the related factors of HP infection in order to provide a scientific basis for the prevention and treatment of Helicobacter pylori in this area. Methods from October 2007 to May 2008, HP infection was investigated in different population groups in Wuwei City. Elisa Elisa was used to detect HP infection rate in 797 adults from urban and rural residents in Wuwei City. A cross-sectional study of factors. (2) HP fecal antigen was detected in 938 children or adolescents aged 318 years and 96 families in Wuwei by Helicobacter pylori antigen detection method. HP virulence protein was analyzed by Helicobacter pylori Western blotting in 80 children or adolescents who were tested positive for HP fecal antigen. Standardized questionnaires were used to collect information on individual disease history, family disease history, risk factors and protective factors. Results 1) the infection rate of HP among adults in Wuwei was 81.8, and with the increase of age, the result of analysis of HP infection showed that HP infection might be related to age, occupation, education level, drinking water source and so on. Multivariate logistic regression analysis showed that occupation, drinking water source, Washing hands before meals and patients with gastric cancer or gastric diseases were the risk factors of HP infection.) the total HP infection rate of children and adolescents in Wuwei City was 72.3%. Parents occupation, drinking source, whether go to kindergarten, eat vegetables raw, brush teeth and breast-feed. Multivariate logistic regression analysis showed that drinking water source, went to kindergarten, Eating raw vegetables was the risk factor of HP infection. The HP infection rate of other members of the family was significantly higher than that of the other members of the HP negative group (P < 0.05. 4). The difference was statistically significant (P < 0. 05, P < 0. 05, P < 0. 05, P < 0. 05, P < 0. 05, P < 0. 05, P < 0. 05, P < 0. 05, P < 0. 05, P < 0. 05, P < 0. 05, P < 0. 05, P < 0. 05). There were 57 cases of type 鈪，

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