深圳市某社区15岁以下人群乙肝疫苗免疫效果评价

发布时间：2018-04-28 13:30

本文选题：乙肝疫苗 + 免疫接种　；参考：《现代预防医学》2014年05期

【摘要】：目的评价深圳市某社区15岁以下人群规范全程接种乙肝疫苗1年后的免疫水平。方法对某社区经检测HBsAg阴性的15岁以下人员按"0、1、6"程序接种乙肝疫苗,符合全程规范接种要求的1 986例对象在接种疫苗1年后进行抗-HBs定性和定量检测。结果 (1)在该小区建立有健康档案的15岁以下各组人群乙肝疫苗全程接种率均在95%以上,平均为96.18%。(2)该1 986名研究对象在接种乙肝疫苗1年后检测抗-HBs,平均抗体阳性率为93.06%,抗-HBs几何平均浓度为267.89 mIU/ml。新生儿组、学龄前组、小学组和初中组抗-HBs阳性率分别为96.46%,94.32%,92.75%和90.02%;平均抗体浓度分别为312.17 mIU/ml,290.33 mIU/ml,265.13 mIU/ml和218.44mIU/ml,组间差异有统计学意义(P0.05)。随着疫苗接种年龄的增大,抗-HBs阳性率和抗体浓度有下降趋势。(3)新生儿组、学龄前组、小学组和初中组抗-HBs阳性率和平均抗体浓度男性之间和女性之间组间差异有统计学意义(P0.05)。但同年龄组男女性之间差异无统计学意义(P0.05)。结论 15岁以下人员接种乙肝疫苗免疫效果良好,年龄越小接种,保护性作用越大。
[Abstract]:Objective to evaluate the immunization level of the population under 15 years of age after inoculating hepatitis B vaccine for one year in a community in Shenzhen. Methods 1 986 patients under 15 years of age who were tested negative for HBsAg in a community were vaccinated with hepatitis B vaccine according to the procedure of "0yang1zao 6". Qualitative and quantitative detection of anti-HBs was carried out in 1 year after inoculation. Results 1) the total coverage rate of hepatitis B vaccine in all groups under 15 years old was over 95%. The average antibody positive rate and geometric average concentration of anti-HBs and anti-HBs were 93.06 and 267.89 mIUP 路ml, respectively, one year after inoculation of hepatitis B vaccine, the average positive rate of anti-HBs was 93.06 and the geometric average concentration of anti-HBs was 267.89 MIUP 路ml. The positive rates of anti-HBs in neonatal group, preschool group, primary school group and junior high school group were 96.46 ~ 94.32, 92.75% and 90.02%, respectively, and the average antibody concentrations were 312.17 m / ml / ml ~ 290.33 m / ml / ml ~ 265.13 mIU/ml and 218.44 m / ml / min, respectively. With the increase of vaccination age, the positive rate and antibody concentration of anti-HBs decreased in neonatal group, preschool group, primary school group and junior high school group. There were significant differences in anti-HBs positive rate and average antibody concentration between males and females. But there was no significant difference between male and female in the same age group (P 0.05). Conclusion the immune effect of hepatitis B vaccine for persons under 15 years old is good, and the younger the age is, the greater the protective effect is.
【作者单位】：深圳市坪山新区人民医院;深圳市盐田区人民医院;
【分类号】：R186

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