一种血液透析机消毒专用过氧乙酸的杀菌效果观察

发布时间：2018-05-03 12:14

本文选题：血液透析机 + 过氧乙酸　；参考：《中国消毒学杂志》2014年04期

【摘要】：目的研究一种血液透析机专用过氧乙酸消毒液杀菌效果及其相关性能。方法用悬液定量、载体浸泡定量杀菌试验以及动物实验方法,对该过氧乙酸消毒液进行实验研究。结果用浓度为500 mg/L该过氧乙酸消毒液对悬液内大肠杆菌和金黄色葡萄球菌作用5 min,可完全杀灭。用浓度为1 220 mg/L该过氧乙酸消毒液对载体上枯草杆菌黑色变种芽孢作用15 min,杀灭对数值3.00。用浓度为2 000 mg/L该过氧乙酸消毒液对模拟现场载体上枯草杆菌黑色变种芽孢浸泡作用15 min,杀灭对数值达到6.36。用浓度3 440 mg/L该过氧乙酸消毒液对染有枯草杆菌黑色变种芽孢的血液透析器浸泡作用180 min,可完全杀灭。该消毒液对小鼠急性经口毒性试验LD50值为1 080 mg/kg(体重);对小鼠骨髓嗜多染红细胞微核试验结果为阴性。结论该消毒液具有良好的杀菌效果,属低毒级物质。
[Abstract]:Objective to study the germicidal efficacy and related properties of peracetic acid disinfectant for hemodialysis machine. Methods suspension quantitative, carrier immersion quantitative germicidal test and animal experiment were used to study the peracetic acid disinfectant. Results the suspension Escherichia coli and Staphylococcus aureus were exposed to the peracetic acid disinfectant at a concentration of 500 mg/L for 5 minutes. The peracetic acid disinfectant at concentration of 1 220 mg/L was applied to Bacillus subtilis var. Niger spores on the carrier for 15 minutes, and the logarithmic value was 3. 00%. After soaking the spores of Bacillus subtilis var. Niger on the simulated field carrier with 2 000 mg/L peracetic acid disinfection solution for 15 min, the logarithmic value of killing was 6.36. The peracetic acid disinfectant with concentration of 3 440 mg/L could completely kill the hemodialyzer infected with spores of Bacillus subtilis var. Niger for 180 minutes. The LD50 value of acute oral toxicity test was 1 080 mg / kg (body weight), and the micronucleus test of mouse bone marrow polychromatic erythrocytes was negative. Conclusion the disinfectant has good bactericidal effect and belongs to low toxic class.
【作者单位】：广东环凯微生物科技有限公司;
【基金】：广东省科技计划项目(编号:2012B010300033);广东省科技计划项目(编号:2011B020314002)
【分类号】：R187

【参考文献】