慢性阻塞性肺疾病流行病学及危险因素的研究进展

发布时间：2018-05-12 19:14

本文选题：慢性阻塞性肺疾病 + 流行病学　；参考：《南昌大学》2017年硕士论文

【摘要】：背景:慢性阻塞性肺疾病(COPD)是最常见的慢性呼吸系统疾病,它可以累及全身各个器官系统。由于COPD病程迁延,患病人数较多,致残率及病死率较高,患者的生活质量受到严重影响,同时也给家庭和社会带来了沉重的经济以及社会负担。COPD危险因素种类繁多,作用机制不尽相同,因此了解COPD的流行病学、识别其各种可干预危险因素,对COPD的防治尤为重要。目的:通过综述COPD的流行病学、各种可干预危险因素及不可干预危险因素方面的研究,为COPD的防治提供一些参考。方法:以“COPD,流行病学,危险因素”等关键词进行搜索,找出COPD流行病学及危险因素方面的最新研究。结论:目前全世界各个地区有大量COPD流行病学及危险因素方面的研究,综合这些研究结果表明:COPD的患病率呈逐年增长的趋势,给家庭及社会带来沉重的经济负担;在COPD众多危险因素中,目前被完全确认的危险因素是吸烟及丝氨酸蛋白酶抑制剂家族基因1;空气污染、职业粉尘暴露、肺的生长发育、体重指数、年龄及其他遗传基因等危险因素与COPD的关系需进一步探索;提高各层面人群对COPD的认知度,尽早对可干预危险因素进行干预,对COPD防治意义重大。
[Abstract]:Background: chronic obstructive pulmonary disease (COPD) is the most common chronic respiratory disease. As the course of COPD is prolonged, the number of patients is large, the rate of disability and mortality is high, the quality of life of the patients is seriously affected, and at the same time, it brings a heavy economic and social burden to the family and society, and there are many kinds of risk factors. The mechanism of action is different, so it is very important to understand the epidemiology of COPD and identify its interventional risk factors for the prevention and treatment of COPD. Objective: to provide some references for the prevention and treatment of COPD by reviewing the epidemiology, interventional risk factors and non-interventional risk factors of COPD. Methods: to find out the latest research on COPD epidemiology and risk factors by searching for the keywords of "copd, epidemiology, risk factors". Conclusion: there are a large number of epidemiology and risk factors of COPD in various regions of the world. The results show that the prevalence of COPD is increasing year by year, which brings a heavy economic burden to families and society. Among the many risk factors for COPD, smoking and serine protease inhibitor family genes 1, air pollution, occupational dust exposure, lung growth and development, body mass index, The relationship between age and other genetic risk factors and COPD should be further explored, and it is of great significance for the prevention and treatment of COPD to improve the recognition of COPD among people at all levels and to intervene in interventional risk factors as soon as possible.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R563.9;R181.3

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