2010年吉林省麻疹疫苗强化免疫效果评价及疑似预防接种异常反应监测分析

发布时间：2018-05-15 15:04

本文选题：麻疹疫苗 + 强化免疫　；参考：《吉林大学》2011年硕士论文

【摘要】：麻疹是严重威胁我国儿童健康的传染病之一,是由麻疹病毒引起的急性、全身性、出疹性呼吸道传染病。在发展中国家,麻疹在幼儿中的病死率可高达5%～10%。由于麻疹病毒只有一个血清型,抗原性非常稳定,麻疹病毒不在动物之间传播,人是麻疹病毒的唯一宿主。因此使用有效安全的疫苗进行预防,消除麻疹在理论层面和操作层面上都具有可行性。因此世界卫生组织已将麻疹列为继消灭天花、脊髓灰质炎之后的第三个将要被消除或消灭的疾病。2006年我国所在的WHO西太区承诺在2012年消除麻疹,中国卫生部下发了《2006—2012年中国消除麻疹行动计划》,我省按照卫生部要求于2010年9月11-20日开展全省范围内8月龄～6岁儿童的麻疹疫苗强化免疫活动。本文通过对此次麻疹疫苗强化免疫活动接种数据和在活动中出现的疑似预防接种异常反应数据的统计分析,对比强化免疫活动前后一年时间吉林省麻疹的发病例数及发病率、其他省份及国家在此次强化免疫活动中出现的疑似预防接种异常反应情况,可以有效的评估吉林省这次全省范围内麻疹疫苗强化免疫活动开展效果,评价此次活动麻疹疫苗接种安全性、疑似预防接种异常反应发生的相关影响因素以及吉林省的疑似预防接种异常反应监测系统运转情况。为吉林省开展消除麻疹行动提供策略依据。
[Abstract]:Measles is one of the infectious diseases that seriously threaten the health of children in our country. It is an acute, systemic and rash respiratory infectious disease caused by measles virus. In developing countries, measles mortality in young children can be as high as 5 / 10. Because measles virus has only one serotype, antigenicity is very stable, measles virus does not spread between animals, human is the only host of measles virus. Therefore, the use of effective and safe vaccines for prevention and measles elimination is theoretically and operationally feasible. Therefore, the World Health Organization has listed measles as the third disease to be eliminated or eliminated after smallpox and polio. In 2006, our country's WHO West District pledged to eliminate measles by 2012. The Ministry of Health of China has issued the "China measles Elimination Action Plan 2006-2012". According to the requirements of the Ministry of Health, our province will carry out an intensified measles vaccination campaign for children aged 8 months or 6 years in the province from September 11 to 20, 2010. Based on the statistical analysis of the vaccination data of the measles vaccine intensive immunization campaign and the abnormal response data of suspected vaccination during the campaign, the number of measles cases and the incidence of measles in Jilin Province before and after the intensive immunization campaign were compared. The abnormal reactions of suspected vaccination in other provinces and countries in this intensive immunization campaign can effectively assess the effectiveness of the measles vaccine intensified immunization campaign in Jilin Province this time. To evaluate the safety of measles vaccination, the related factors of abnormal reaction of suspected vaccination, and the operation of abnormal response monitoring system of suspected vaccination in Jilin province. To provide strategic basis for carrying out measles elimination in Jilin province.
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R186

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