上海市青浦区民工子弟学校新生强化免疫前麻疹血清流行病学横断面调查

发布时间：2018-05-19 16:53

本文选题：民工子弟学校 + 麻疹　；参考：《复旦学报(医学版)》2014年05期

【摘要】：目的掌握上海市青浦区民工子弟学校新生强化免疫前的麻疹免疫水平。方法采用多阶段抽样方法,抽取民工子弟学校新生606名,采用定量ELISA测定调查对象血清中的麻疹IgG抗体水平,同时调查就学史、麻疹相关疫苗接种史、麻疹患病史等情况。结果民工子弟学校新生强化免疫前麻疹IgG抗体几何平均浓度(geometric mean of concentration,GMC)为998.96 mIU/mL(95%CI,912.93~1093.10),阳性率为94.88%。不同学校类别(幼托、小学、初中)对象的GMC差异无统计学意义(F=1.19,P=0.30),抗体阳性率差异无统计学意义(χ2=0.36,P=0.83);不同就学史(此前无就学史、于户籍地就学、于上海其他学校就学)对象的GMC差异无统计学意义(F=1.22,P=0.30),抗体阳性率差异无统计学意义(χ2=3.46,P=0.18);38.29%调查对象无预防接种证或已经丢失,麻疹相关疫苗接种≥2剂次者占37.95%,接种史不详者占48.18%,不同接种史对象的GMC差异无统计学意义(F=0.75,P=0.53)。结论上海市青浦区民工子弟学校新生强化免疫前麻疹抗体水平及抗体阳性率均处于较高水平,但不能提供明确麻疹疫苗接种史是其中一个突出问题,预防接种证的管理和入托/入园、入学接种证查验工作是外来民工子弟学校学生免疫规划工作的薄弱环节。
[Abstract]:Objective to understand the measles immunization level of freshmen in Qingpu District before intensive immunization. Methods A total of 606 freshmen from the school of migrant workers were sampled by multi-stage sampling. The measles IgG antibody levels in the serum of the subjects were determined by quantitative ELISA. The history of school attendance, measles related vaccination and measles disease were investigated at the same time. Results the geometric average concentration of measles IgG antibody before intensive immunization was 998.96 mIUU / mL / 95CIQ 912.93 / 1093.10 / 10, and the positive rate was 94.88%. There was no significant difference in GMC between different school types (kindergarten, primary school, junior middle school), but there was no significant difference in antibody positive rate (蠂 ~ 2 / 0.36). There was no significant difference in GMC among the subjects enrolled in other schools in Shanghai. There was no significant difference in the positive rate of antibody between the two groups (蠂 2, 3.46, P < 0. 188.29%). 37.95 cases were inoculated with more than 2 doses of measles vaccine and 48.18 cases with unknown vaccination history. There was no significant difference in GMC between different inoculation history subjects (P < 0.53). Conclusion the level of measles antibody and the positive rate of measles antibody in the freshmen of the school of migrant workers in Qingpu District of Shanghai are all at a high level, but it is an outstanding problem to provide a clear history of measles vaccination. The administration of vaccination card and the examination of school entrance certificate are the weak links in the immunization planning of the school students of migrant workers' children.
【作者单位】：上海市青浦区疾病预防控制中心急性传染病防制科;复旦大学公共卫生学院卫生微生物学教研室-公共卫生安全教育部重点实验室;
【基金】：上海市青浦区科学技术发展基金项目(2009-41)~~
【分类号】：R186.3

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