兰州地区腹泻患儿中人博卡病毒1~4型流行病学研究

发布时间：2018-05-22 08:44

本文选题：腹泻 + 人博卡病毒　；参考：《病毒学报》2014年04期

【摘要】：了解兰州地区病毒性腹泻患儿中人博卡病毒1~4型(HBoV1~4型)的流行情况及临床特点,并探讨HBoV与急性胃肠炎的疾病相关性。收集兰州大学第一医院2012年7月至2013年6月5岁以下腹泻患儿的粪便标本331份,采用PCR方法检测人博卡病毒,同时检测常见的肠道病毒。331份标本中共检出博卡阳性标本49例(14.80%),其中HBoV1~4型分别检测出26例、15例、7例和1例。分析其流行规律发现HBoV相关的腹泻全年散发,无明显季节分布。HBoV感染的患儿年龄为11.04±6.92月龄,高发年龄是7~12月龄。2岁以下患儿占HBoV阳性患儿总数的93.88%。HBoV与其他病毒混合感染率为71.3%,以混合轮状病毒为主。HBoV感染对腹泻患儿的发热和呕吐发生率无明显影响。检测出一例罕见的HBoV4病毒LZFB086,与泰国(序列号JQ267789)参考株的同源性为99.0%。未检测出HBoV2B型。从研究结果得出我国兰州地区人博卡病毒以HBoVl为主,在我国首次发现HBoV4病毒。HBoV1~4与其他病毒的混合感染率高,主要是混合轮状病毒。HBoV可能不是导致急性胃肠炎的致病病原。
[Abstract]:To investigate the prevalence and clinical characteristics of human Boca virus type 1 / 4 (HBoV1 / 4) in children with viral diarrhea in Lanzhou area, and to explore the correlation between HBoV and the disease of acute gastroenteritis. From July 2012 to June 2013, 331 fecal specimens of children under 5 years of age with diarrhea were collected from the first Hospital of Lanzhou University. Human Boca virus was detected by PCR method. A total of 49 Boca positive specimens were detected, including 26 cases of HBoV1~4 type, 15 cases of Boca positive specimens and 1 case of Boca positive specimens. It was found that the age of children with HBoV associated diarrhea was 11.04 卤6.92 months old. The mixed infection rate of 93.88%.HBoV and other viruses in children under 12 months of age from 7 to 12 months old was 71.30.The incidence of fever and vomiting in children with diarrhea was not significantly affected by mixed rotavirus infection. A rare case of HBoV4 virus LZFB086 was detected. The homology of LZFB086was 99.0 with the reference strain of Thailand (serial number JQ267789). No HBoV2B type was detected. From the results of the study, it is concluded that HBoVl is the main type of human Boca virus in Lanzhou area of China, and the mixed infection rate of HBoV4 virus. HBoV1P4 with other viruses is high for the first time in China. The main reason is that mixed rotavirus. HBoV may not be the causative agent of acute gastroenteritis.
【作者单位】：兰州大学第一医院儿科;中国疾病控制预防控制中心病毒病预防控制所病毒性腹泻室;宁夏医科大学检验学院;
【分类号】：R181.3;R725.1

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