老年住院患者非呼吸道侵袭性真菌感染的流行病学及危险因素分析

发布时间：2018-06-06 18:32

本文选题：非呼吸道 + 真菌感染　；参考：《中国老年学杂志》2014年12期

【摘要】：目的探讨老年住院患者非呼吸道侵袭性真菌感染(IFI)的流行病学状况及其相关危险因素。方法选取2010年6月至2013年6月该院有完整病历资料的老年住院患者非呼吸道IFI者78例,非IFI者386例,对其感染真菌进行分离检测,并记录相关指标。老年住院患者非呼吸道相关危险因素分析采用非条件Logistic回归。结果 78例非呼吸道IFI老年住院患者中共检测分离出真菌87株。其中尿中检测出29株(33.33%),为标本检出真菌排名首位。分离出假丝酵母菌84株(96.55%),为检出最多的菌株。单因素分析提示,老年住院患者非呼吸道IFI危险因素有年龄、病程、住院时间、病原检测时间、白细胞数、中性粒细胞数、白蛋白数、体温37.5℃、抗生素种类、使用激素、使用免疫抑制剂、预防性抗真菌治疗、有创的检查和治疗、呼吸系统疾病、内分泌系统疾病、泌尿系统疾病、消化系统疾病和神经系统疾病(P0.05)。多因素Logistic回归分析,老年住院患者非呼吸道IFI危险因素有年龄、病原菌检测时间、消化系统普通疾病和神经系统普通疾病,老年住院患者非呼吸道IFI保护因素有呼吸系统疾病(P0.05)。结论老年住院患者非呼吸道IFI主要为假丝酵母菌。早期诊治基础疾病、合理规范应用检查和治疗手段是预防老年住院患者真菌感染的关键。
[Abstract]:Objective to investigate the epidemiological status and related risk factors of non respiratory invasive fungal infection (IFI) in elderly hospitalized patients. Methods 78 cases of non respiratory IFI in elderly hospitalized patients with complete medical records from June 2010 to June 2013 were selected and 386 cases of non IFI were selected, and their infected fungi were separated and detected, and the related indexes were recorded. Non respiratory related risk factors were analyzed by non conditional Logistic regression in elderly hospitalized patients. Results 87 strains of fungi were detected in 78 non respiratory IFI elderly hospitalized patients. Among them, 29 strains (33.33%) were detected in urine, and 84 strains of Candida (96.55%) were isolated from the samples, which were the most detected strains. Factor analysis suggested that the risk factors of non respiratory IFI in elderly hospitalized patients were age, course of disease, time of hospitalization, time of detection of pathogens, number of leukocytes, neutrophils, albumin, temperature at 37.5, antibiotics, use of hormones, immunosuppressive agents, preventive antifungal therapy, invasive examination and treatment, respiratory diseases, internal components. Systemic disease, urinary system disease, digestive system disease and nervous system disease (P0.05). Multiple factor Logistic regression analysis, non respiratory IFI risk factors in elderly hospitalized patients are age, detection time of pathogenic bacteria, common diseases of digestive system and common diseases of nervous system, non respiratory IFI protection factors in elderly hospitalized patients have respiratory system P0.05. Conclusion non respiratory IFI in elderly patients is mainly Candida albicans. Early diagnosis and treatment of basic diseases, rational use of examination and treatment are the key to prevent fungal infection in elderly hospitalized patients.
【作者单位】：东方市人民医院内科;
【分类号】：R519;R181.3

【参考文献】