石河子市流行性腮腺炎流行特征及免疫状况分析

发布时间：2018-06-23 14:21

本文选题：流行性腮腺炎 + 流行病学特征　；参考：《新疆医科大学》2011年硕士论文

【摘要】：目的：对石河子市2005年-2009年传染病网络直报系统流行性腮腺炎病例资料进行统计学分析,了解石河子市流行性腮腺炎的发病情况。对石河子市1～8岁儿童接种流行性腮腺炎疫苗后的抗体阳性率进行分析,了解石河子市儿童接种腮腺炎疫苗后的抗体水平,为制定和调整流行性腮腺炎预防控制策略提供依据。方法：1.采用回顾性调查的方法对石河子市2005～2009年流行性腮腺炎疫情资料进行描述流行病学分析。2.应用现况调查对石河子市1～8岁接种过流行性腮腺炎活疫苗的儿童,用组群抽样的抽样方法,随机抽取769名,采用血清间接酶联免疫法定性测定腮腺炎抗体IgG。结果：1.石河子市2005-2009年共报告流行性腮腺炎771例,年平均发病率45.95/10万,发病率总体呈现明显的上升趋势,发病有明显的季节性,6月的病例报告最多,在春夏之交形成明显的发病高峰,男性发病明显超过女性,男女性别比是1.909：1,4～19岁占报告病例总数的83.11%,学生占报告病例总数的71.08%,学龄前儿童占报告病例总数的22.31%,病例中有腮腺炎疫苗免疫史占31.65%；病例中1～8岁儿童中,有腮腺炎疫苗免疫史的占48.77%。2.对石河子市1～8岁儿童腮腺炎免疫状况调查,1～8岁儿童腮腺炎抗体阳性率平均为54.23%,1～岁组的抗体阳性率最低(31.15%),2～岁组抗体阳性率最高(67.19%),2～岁组以后随年龄的增长抗体水平呈逐渐下降趋势,并进行趋势卡方检验有显著的统计学意义(X2=477.22,P0.005),男女间腮腺炎抗体阳性率无显著性差异(X2=0.077,P0.05),常住儿童抗体阳性率高于暂住人口(X2=3.92,P0.05),有显著性差异。结论：1.石河子市2005-2009年腮腺炎发病率总体呈现明显的上升趋势,发病有明显的季节性,男性发病高于女性,以集体生活为主的在校学生,是危险性较大的群体,发病人群中接种率较低。2.石河子市1～8岁儿童腮腺炎疫苗免疫后抗体阳性率较低,并随着年龄的增长抗体水平有下降的趋势,接种1剂次腮腺炎疫苗后,腮腺炎抗体阳性率处于较低水平,建议采取2剂次的接种方案。
[Abstract]:Objective: to study the incidence of epidemic mumps in Shihezi city from 2005 to 2009 by statistical analysis of epidemic mumps cases. The positive rate of antibody after inoculation of mumps vaccine in children aged 1 to 8 years old in Shihezi city was analyzed, and the antibody level of children in Shihezi city after inoculation of mumps vaccine was understood. To provide the basis for formulating and adjusting the prevention and control strategy of mumps. Method 1: 1. The epidemic data of mumps from 2005 to 2009 in Shihezi city were analyzed by retrospective investigation. A survey was conducted on 769 children who had been vaccinated with live mumps vaccine for mumps in Shihezi city aged 1 ~ 8 years, and 769 cases were randomly selected by cluster sampling, and IgG of mumps antibody was determined qualitatively by indirect enzyme-linked immunosorbent assay (Elisa) in serum. The result is 1: 1. A total of 771 cases of mumps were reported in Shihezi City from 2005 to 2009, with an average annual incidence rate of 45.95% / 10 million. The incidence rate showed an obvious upward trend, and the incidence rate was obviously seasonal. The most cases were reported in June, and the peak incidence occurred between spring and summer. The incidence rate of male was significantly higher than that of female. The ratio of male to female was 1.909: 1: 40.19 years old, accounting for 83.11% of the total reported cases, students accounted for 71.08% of the total reported cases, preschool children accounted for 22.31% of the total reported cases, and the mumps vaccine immunization history accounted for 31.65% in the cases. Among children aged 1 to 8 years, 48.77. 2 had a history of mumps vaccine immunization. An investigation on the immune status of mumps in children aged 1 ~ 8 years old in Shihezi City. The average positive rate of mumps antibody in children aged 8 years is 54.23 years old, the lowest (31.15%) is the antibody positive rate of mumps antibody in the group of 2 ~ year old (67.19%), and the positive rate of antibody is the highest in the group of 2 ~ years of age. The increase of antibody level showed a decreasing trend, The positive rate of mumps antibody was not significantly different between male and female (X2 + 0.07 0. 05), and the positive rate of antibody in resident children was higher than that in transient population (X2 + 3. 92P 0.05), and there was a significant difference in the positive rate of mumps antibody between male and female. Conclusion 1. The incidence of mumps in Shihezi city from 2005 to 2009 showed an obvious upward trend, and the incidence of mumps was obviously seasonal. The incidence of male was higher than that of female. The positive rate of mumps antibody in children aged 1 to 8 years old in Shihezi city was lower after immunization, and the antibody level decreased with the increase of age. The positive rate of mumps antibody was at a lower level after inoculating 1 dose of mumps vaccine. Two doses of inoculation were recommended.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：R181.3

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