广州及周边地区蝙蝠携带SARS（样）冠状病毒、狂犬病毒和禽流感病毒的初步流行病学调查

发布时间：2018-07-03 16:50

本文选题：SARS(样)冠状病毒 + 狂犬病毒　；参考：《第一军医大学》2006年博士论文

【摘要】：研究背景：蝙蝠对人类而言是有益的动物，是一个可以与人类和谐共处的重要物种，但是近年来发现蝙蝠是多种人兽共患疾病病毒的储存宿主，如近来在澳大利亚和东亚出现的尼巴病毒及亨德拉病毒。蝙蝠可以持续感染许多病毒而不表现临床症状。SARS首先在广东爆发，尽管先前对这种新病毒的致病性和分子特征的研究取得了成功，但仍没有找到SARS冠状病毒的来源。流行病学调查及果子狸体内检测到SARS样病毒，表明SARS冠状病毒(serveacute respiratory syndrome-associated coronavirus，SARS-CoV)可能来自野生动物，但随后的调查发现感染在野生或人工饲养的果子狸并不常见，而且果子狸在感染两种不同的SARS-CoV人分离株后，表现出明显的临床症状，提示果子狸可能不是SARS-CoV的自然宿主。果子狸可能只是SARS-CoV的中间宿主，SARS-CoV有可能是从别的野生动物(如在野生动物市场的野生动物)传播给果子狸。广东地区有食用果蝠的现象，，野生动物市场每天汇集来自广州
[Abstract]:Background: bats are beneficial animals to humans and an important species that can live in harmony with human beings. However, bats have been found to be the storage hosts of many zoonotic diseases and viruses in recent years. Such as the recent emergence of Niba and Hendra viruses in Australia and East Asia. Bats can continue to infect many viruses without showing clinical symptoms. SARS first broke out in Guangdong. Although previous studies on the pathogenicity and molecular characteristics of the new virus have been successful, the source of SARS coronavirus has not been found. Epidemiological investigation and detection of SARS-like virus in civet showed that SARS-CoV (serveacute respiratory syndrome-associated coronavirusSARS-CoV) might come from wild animals. After two different isolates of SARS-CoV were infected, the civets showed obvious clinical symptoms, suggesting that the civets may not be the natural hosts of SARS-CoV. The civets may only be the intermediate host of SARS-CoV, which may be transmitted from other wild animals, such as those in the wildlife market, to the civets. There is a phenomenon of edible fruit bats in Guangdong. The wild animals market comes from Guangzhou every day.
【学位授予单位】：第一军医大学
【学位级别】：博士
【学位授予年份】：2006
【分类号】：R181.3

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