一种泡沫型苯扎氯铵手消毒剂杀菌效果及毒性观察

发布时间：2018-07-11 17:49

本文选题：苯扎氯铵 + 杀菌效果　；参考：《中国消毒学杂志》2017年08期

【摘要】：目的观察一种泡沫型苯扎氯铵手消毒剂的杀菌效果及评价其毒性。方法采用悬液定量杀菌试验、现场试验和动物试验方法,对该消毒剂的杀菌效果和毒性进行研究。结果该手消毒剂原液含苯扎氯铵1.35 g/L,p H值3.31;以该手消毒剂作用0.5 min,对悬液内大肠杆菌和金黄色葡萄球菌杀灭对数值均5.00,对白色念珠菌杀灭对数值4.00;对手上自然菌作用1.0 min的杀灭对数值平均值为1.65;该手消毒剂密封储存于37℃恒温恒湿箱内90 d后,苯扎氯铵含量下降率为2.96%;其原液急性经口毒性LD505 000 mg/(kg·bw),对家兔皮肤无刺激性,小鼠骨髓嗜多染红细胞微核试验结果为阴性。结论该泡沫型苯扎氯铵手消毒剂具有良好的杀菌效果与稳定性,属于实际无毒级、无致突变作用、无刺激性的消毒剂。
[Abstract]:Objective To observe the bactericidal effect of a foam type benzalkonium chloride hand disinfectant and evaluate its toxicity. Methods the suspension quantitative germicidal test, field test and animal test method were used to study the bactericidal effect and toxicity of the disinfectant. The results showed that the disinfectant contained 1.35 g/L of benzalkonium chloride and 3.31 P H value, and the effect of the hand disinfectant was 0.5 m. In, the killing values of Escherichia coli and Staphylococcus aureus were 5 and 4 for Candida albicans; the average value of the killing of natural bacteria on the opponent's natural bacteria 1 min was 1.65. After the hand disinfectant was sealed at 90 d in the constant temperature and constant humidity box of 37 centigrade, the decrease rate of benzalkonium chloride was 2.96%. The sex LD505 000 mg/ (kg. BW) had no irritation to the skin of the rabbit, and the result of micronucleus test of the murine bone marrow polychromatic erythrocytes was negative. Conclusion the foam type benzalkonium chloride hand disinfectant has good bactericidal effect and stability, which belongs to the actual nontoxic grade, no mutagenicity, and no prickly irritation disinfectant.
【作者单位】：辽宁省疾病预防控制中心;
【分类号】：R187.2

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