四川省西昌市吸毒人群HIV和HCV感染及其危险因素研究

发布时间：2018-10-09 08:47

【摘要】：目的:(1)了解四川省凉山彝族自治州西昌市的吸毒人群首次吸毒的发生情况以及影响因素;(2)了解男性吸毒人群的高危性行为特征;(3)了解吸毒人群的HBsAg、 HCV和HIV的感染率及其相关危险因素。方法:(1)于2004年5～7月在四川省凉山彝族自治州西昌市招募吸毒人员1070 人,采用统一的调查表调查吸毒人群的社会人口学特征、吸毒行为以及性行为情况。对采集的血样进行艾滋病病毒抗体、乙型肝炎病毒表面抗原、丙型肝炎病毒抗体和梅毒螺旋体抗体的检测。(2)统计方法包括:统计描述,Cox比例风险模型,x~2检验, 单因素Logistic回归模型,多因素Logistic回归模型。结果:(1)研究对象从出生到首次吸毒的发生率为4.08/100人年。15岁以前开始吸烟者与朋友中吸毒人数多者发生首次吸毒时间早。吸毒者在吸毒前他们朋友中吸毒的人数与他们首次吸毒的发生率有一定的关系。(2)研究对象与其主要性伴间的性行为频率随着吸毒年限的增长而减少;而与非主要性伴间的性行为随着近期静脉注射毒品频率的增高可能性增大。(3)研究对象HBsAg阳性率为12.6%。彝族和共用注射器具吸毒伙伴人数多者HBsAg阳性率高。(4)研究对象HCV感染率为55.9%。曾经静脉吸毒和曾经共用针头或注射器具吸毒者HCV感染率高。(5)研究对象HIV感染率为8.6%。彝族和共用注射器具吸毒伙伴人数多者HIV感染率高。至今共用注射器具吸毒的伙伴总人数是HIV感染的独立危险因素。结论:与以往数据比较,吸毒人群HBsAg,HCV,HIV的感染率均呈上升趋势, 故对这个人群需要加强宣传教育和行为干预以减少其高危行为从而预防多种疾病的传播。
[Abstract]:Objective: (1) to understand the incidence and influencing factors of first time drug abuse among drug users in Xichang City, Liangshan Yi Autonomous Prefecture, Sichuan Province; (2) to understand the high risk of male drug users. (3) to understand the infection rate of HBsAg, HCV and HIV in drug users and its risk factors. Methods: (1) 1070 drug addicts were recruited from May to July 2004 in Xichang, Liangshan Yi Autonomous Prefecture, Sichuan Province. Drug abuse and sexual behaviour. The collected blood samples were treated with HIV antibody, hepatitis B virus surface antigen, Detection of hepatitis C virus antibodies and spirochetes virus antibodies. (2) Statistical methods include: statistical description of Cox proportional risk model, Univariate Logistic regression model, Multivariate Logistic regression model. Results: (1) the incidence of drug abuse in subjects from birth to first time was 4.08 / 100 person-years. The number of drug addicts in their friends before taking drugs was related to the incidence of their first drug use. (2) the sex between the subjects and their main sexual partners. The frequency of behavior decreases with the increase of the number of years of drug abuse. But sexual behavior with non-main sexual partners increased with the increasing frequency of intravenous drug injection in the near future. (3) the positive rate of HBsAg was 12.6%. The positive rate of HBsAg was higher in the Yi nationality and the partners who used common injector. (4) the HCV infection rate was 55.995%. The infection rate of HCV among intravenous drug users and drug users who had shared needles or injectors was high. (5) the rate of HIV infection was 8.6%. The infection rate of HIV was higher in Yi nationality and drug partners who shared injection equipment. The total number of drug partners sharing injecting devices so far is an independent risk factor for HIV infection. Conclusion: compared with previous data, The infection rate of HBsAg,HCV,HIV among drug users is on the rise, so it is necessary to strengthen propaganda and education and behavioral intervention to reduce their high risk behaviors and prevent many diseases. The spread of
【学位授予单位】：苏州大学
【学位级别】：硕士
【学位授予年份】：2005
【分类号】：R181.3

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