苏州市0～4岁儿童乙肝疫苗免疫效果观察

发布时间：2018-10-16 20:50

【摘要】：目的评价0~4岁儿童接种乙肝疫苗的免疫效果,探讨乙肝疫苗加强免疫可行性。方法采用多级、随机整群抽样方法,抽取苏州市部分市、区0~4岁已接种乙肝疫苗的儿童为研究对象,检测血清中乙肝病毒5项血清学标志物。结果本次调查苏州市的877名儿童,乙肝疫苗全程接种率93.16%,0~4岁儿童HBsAg阳性率为0.11%,HBsAb阳性率为74.57%,HBeAg阳性率为0,HBeAb阳性率为2.17%,HBcAb为1.25%。不同年龄组间HBsAb阳性率差异有统计学意义(χ2=134.33,P0.01),HBsAb阳性率随着年龄的增长而呈逐年下降趋势(χ2趋势性检验=108.24,P0.01)。HBsAb阳性率与年龄、免疫次数和全程是否及时等因素有关。结论苏州市0~4岁儿童乙肝疫苗全程接种率较高,HBsAb阳性率随着年龄的增长而呈逐年下降趋势。建议本地区可推行4岁及以上儿童乙肝疫苗加强免疫策略。
[Abstract]:Objective to evaluate the immune effect of hepatitis B vaccine in children aged 0 ~ 4 years, and to explore the feasibility of hepatitis B vaccine immunization. Methods multistage random cluster sampling was used to detect 5 serological markers of hepatitis B virus in serum of children who had been vaccinated with hepatitis B vaccine in 4 years old in some cities and districts of Suzhou. Results among 877 children in Suzhou, the rate of hepatitis B vaccine vaccination was 93.160.The positive rate of HBsAg in children aged 4 years was 0.11 and the positive rate of HBeAg was 74.577.The positive rate of HBeAg was 2.17 and the positive rate of HBcAb was 1.25. There was a significant difference in HBsAb positive rate among different age groups (蠂 ~ 2 / 134.33 / P ~ (0.01), HBsAb positive rate decreased with age (蠂 ~ (2) trend test = 108.24p _ (0.01) P _ (0.01). HBsAb positive rate was related to age, times of immunization and whether the whole process was timely or not). Conclusion the total coverage rate of hepatitis B vaccine in children aged 0 to 4 years old in Suzhou is higher, and the positive rate of HBsAb is decreasing year by year with the increase of age. It is suggested that children aged 4 years and above should be immunized against hepatitis B vaccine.
【作者单位】：苏州市疾病预防控制中心传染病防制科;苏州大学医学部公共卫生学院流行病与卫生统计教研室;苏州市疾病预防控制中心检验科;
【基金】：2011年苏州市“科教兴卫”青年科技项目(KJXW2011033)
【分类号】：R186

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