天津市葡萄球菌临床株流行病学和遗传背景的研究
发布时间：2018-10-18 08:26
【摘要】：为了解天津地区MRSA以及MRCoNS的流行趋势,本研究在2002年7月至2004年6月,连续2年收集了天津市某三级甲等医院分离的葡萄球菌临床株,分析了MRSA的分离率,危险因素和流行趋势。同时对部分近年来天津市感染疾病研究所收集的天津市八所三级甲等医院分离的葡他球菌临床株进行了基因分型研究。初步了解本地区的MRSA的遗传特性。 第一部分 天津市葡萄球菌临床分离株的药物敏感性和临床资料分析 目的: 1) 了解本地区MRSA和MRCoNS的地区流行情况及趋势,为临床经验性治疗以及制定控制MRSA的传播的措施提供理论依据。 2) 筛选来自临床感染病人的致病金葡菌和携带金葡菌,以了解金葡菌携带与感染之间是否存在相关性。 方法: 1) 收集天津市某三级甲等医院(A医院)2002年7月～2004年6月两年期间分离自医院感染病人的葡萄球菌临床株。以2003年6月30日是界限划分年度。采用微量肉汤稀释法测定12种临床常用抗生素,包括:青霉素,苯唑青霉素,氨苄青霉素,环丙沙星,四环素,头孢唑啉,氯霉素,林可霉素,庆大霉素,头孢三嗪,万古霉素,红霉素等的药物敏感性,并分析临床资料。
[Abstract]:In order to understand the epidemic trend of MRSA and MRCoNS in Tianjin, the clinical strains of Staphylococcus isolated from a hospital of Grade 3A in Tianjin were collected for 2 years from July 2002 to June 2004, and the isolation rate of MRSA was analyzed. Risk factors and epidemic trends At the same time, the genotyping of some clinical strains of Staphylococcus isolated from eight hospitals of Grade 3A in Tianjin were studied in recent years. To understand the genetic characteristics of MRSA in this area. The first part: drug sensitivity and clinical data analysis of clinical isolates of Staphylococcus in Tianjin. 1) to know the epidemic situation and trend of MRSA and MRCoNS in this area, To provide a theoretical basis for clinical empirical therapy and to establish measures to control the spread of MRSA. 2) screening pathogenic Staphylococcus aureus and Staphylococcus aureus from clinically infected patients. To understand whether there is a correlation between staphylococcus aureus carrying and infection. Methods: 1) Staphylococcus strains isolated from patients with nosocomial infection from July 2002 to June 2004 in a Grade 3A Hospital (A Hospital) in Tianjin were collected. Take June 30, 2003 as the year of demarcation. Trace broth dilution method was used to determine 12 commonly used antibiotics, including penicillin, oxazolpenicillin, ampicillin, ciprofloxacin, tetracycline, cefazolin, chloramphenicol, lincomycin, gentamycin, ceftriaxine, ceftriaxine. Vancomycin, erythromycin and other drug sensitivity, and analysis of clinical data.
【学位授予单位】：天津医科大学
【学位级别】：博士
【学位授予年份】：2005
【分类号】：R181.3
[Abstract]:In order to understand the epidemic trend of MRSA and MRCoNS in Tianjin, the clinical strains of Staphylococcus isolated from a hospital of Grade 3A in Tianjin were collected for 2 years from July 2002 to June 2004, and the isolation rate of MRSA was analyzed. Risk factors and epidemic trends At the same time, the genotyping of some clinical strains of Staphylococcus isolated from eight hospitals of Grade 3A in Tianjin were studied in recent years. To understand the genetic characteristics of MRSA in this area. The first part: drug sensitivity and clinical data analysis of clinical isolates of Staphylococcus in Tianjin. 1) to know the epidemic situation and trend of MRSA and MRCoNS in this area, To provide a theoretical basis for clinical empirical therapy and to establish measures to control the spread of MRSA. 2) screening pathogenic Staphylococcus aureus and Staphylococcus aureus from clinically infected patients. To understand whether there is a correlation between staphylococcus aureus carrying and infection. Methods: 1) Staphylococcus strains isolated from patients with nosocomial infection from July 2002 to June 2004 in a Grade 3A Hospital (A Hospital) in Tianjin were collected. Take June 30, 2003 as the year of demarcation. Trace broth dilution method was used to determine 12 commonly used antibiotics, including penicillin, oxazolpenicillin, ampicillin, ciprofloxacin, tetracycline, cefazolin, chloramphenicol, lincomycin, gentamycin, ceftriaxine, ceftriaxine. Vancomycin, erythromycin and other drug sensitivity, and analysis of clinical data.
【学位授予单位】：天津医科大学
【学位级别】：博士
【学位授予年份】：2005
【分类号】：R181.3
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