苯那普利降压疗效的临床流行病学研究
发布时间：2018-11-04 17:18
【摘要】：目的: 分别探讨低密度脂蛋白受体相关蛋白8(LRP8)和神经肽Y2受体基因多态性对苯那普利降压疗效的影响。 方法: 选取中国安徽某两地区原发性高血压患者,服用苯那普利,每日10mg,追踪观察15天。测量服药前后血压值,调查人口学特征、测定其基因型并了解其分布特点,从其中选取降压疗效最好和最差的研究对象422人,研究苯那普利的降压疗效和LRP8及NPY2R基因的多态性的关系。 结果: 一LRP8基因多态性和苯那普利降压疗效的关系:(1) 研究人群在LRP8基因的不同基因型间年龄、体重、体质指数、基线收缩压、舒张压下降值、当前是否吸烟、饮酒等因素差异均无显著性;(2) HWE平衡检验未发现三种基因型的频率有显著性差异(x~2=3.45,p=0.063);(3) LRP8的基因突变后影响苯那普利的降压疗效,①在BMI24kg/m~2的原发性高血压人群中LRP8的基因的突变组(AC)能使收缩压比野生型(AA)的人群下降5.68mmHg(校正前β±SE:5.52±2.89mmHg,p=0.0562,校正后β±SE:5.68±2.52mmHg,p=0.0403);②在轻度原发性高血压人群中(159=SBP=140mmHg or 99=DBP=90mmHg),LRP8的基因突变组(AC)能使收缩压和舒张压比野生型(AA)的人群分别下降6.14mmHg和3.81mmHg(收缩压校正前β±SE:6.22+2.71mmHg,p=0.0215,校正后β±SE:6.14±2.58mmHg,p=0.0172;舒张压校正前β±SE:3.69+1.95mmHg,p=0.0588,校正后β±SE:3.81±1.84mmHg,p=0.0387)。 二NPY2R基因多态性和苯那普利降压疗效的关系:(1) 研究人群在不同基因型间体重、腰围、腰臀比差异有显著性(p值分别为0.0322、0.0099和0.0108),
[Abstract]:Aim: to investigate the effects of low density lipoprotein receptor associated protein 8 (LRP8) and neuropeptide Y 2 receptor gene polymorphism on the antihypertensive effect of benazepril. Methods: 10 mg benazepril was administered to patients with essential hypertension in Anhui province of China for 15 days. Blood pressure was measured before and after medication, demographic characteristics were investigated, genotypes were determined and their distribution characteristics were investigated. 422 subjects with the best and worst antihypertensive effects were selected from the study. To study the relationship between the antihypertensive effect of benazepril and the polymorphism of LRP8 and NPY2R gene. Results: the relationship between the polymorphism of a LRP8 gene and the antihypertensive effect of benazepril: (1) the age, body weight, body mass index, baseline systolic blood pressure, diastolic blood pressure (DBP) of different genotypes of LRP8 gene were studied. There was no significant difference between smoking and drinking. (2) there was no significant difference in the frequency of the three genotypes by HWE equilibrium test (x2 + 3.45%). (3) the antihypertensive effect of benazepril was affected by LRP8 gene mutation. 1the mutation group (AC) of LRP8 gene in BMI24kg/m~2 patients with essential hypertension could reduce the systolic blood pressure (SBP) to 5.68mmHg (尾 卤SE:5.52 卤2.89mm HgGG 0.0562 before correction, 尾 卤SE:5.68 卤2.52mmHg after correction) compared with those of wild-type (AA). P0. 0403); 2in mild essential hypertension (159=SBP=140mmHg or 99=DBP=90mmHg), (AC) of LRP8 gene mutation group decreased 6.14mmHg and 3.81mmHg (尾 卤SE:6.22 2.71mm Hg before systolic blood pressure correction) compared with wild-type (AA) patients. After correction, 尾 卤SE:6.14 卤2.58mm HgGG was 0.0172; Diastolic blood pressure (尾 卤SE:3.69 1.95mm) was 0.0588mm, and 尾 卤SE:3.81 卤1.84mm HgGG (0.0387). The relationship between the polymorphism of NPY2R gene and the antihypertensive effect of benazepril: (1) there were significant differences in body weight, waist circumference and waist-to-hip ratio among different genotypes (p = 0.0322 卤0.0099 and 0.0108, respectively).
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2005
【分类号】：R181.3
本文编号：2310594
[Abstract]:Aim: to investigate the effects of low density lipoprotein receptor associated protein 8 (LRP8) and neuropeptide Y 2 receptor gene polymorphism on the antihypertensive effect of benazepril. Methods: 10 mg benazepril was administered to patients with essential hypertension in Anhui province of China for 15 days. Blood pressure was measured before and after medication, demographic characteristics were investigated, genotypes were determined and their distribution characteristics were investigated. 422 subjects with the best and worst antihypertensive effects were selected from the study. To study the relationship between the antihypertensive effect of benazepril and the polymorphism of LRP8 and NPY2R gene. Results: the relationship between the polymorphism of a LRP8 gene and the antihypertensive effect of benazepril: (1) the age, body weight, body mass index, baseline systolic blood pressure, diastolic blood pressure (DBP) of different genotypes of LRP8 gene were studied. There was no significant difference between smoking and drinking. (2) there was no significant difference in the frequency of the three genotypes by HWE equilibrium test (x2 + 3.45%). (3) the antihypertensive effect of benazepril was affected by LRP8 gene mutation. 1the mutation group (AC) of LRP8 gene in BMI24kg/m~2 patients with essential hypertension could reduce the systolic blood pressure (SBP) to 5.68mmHg (尾 卤SE:5.52 卤2.89mm HgGG 0.0562 before correction, 尾 卤SE:5.68 卤2.52mmHg after correction) compared with those of wild-type (AA). P0. 0403); 2in mild essential hypertension (159=SBP=140mmHg or 99=DBP=90mmHg), (AC) of LRP8 gene mutation group decreased 6.14mmHg and 3.81mmHg (尾 卤SE:6.22 2.71mm Hg before systolic blood pressure correction) compared with wild-type (AA) patients. After correction, 尾 卤SE:6.14 卤2.58mm HgGG was 0.0172; Diastolic blood pressure (尾 卤SE:3.69 1.95mm) was 0.0588mm, and 尾 卤SE:3.81 卤1.84mm HgGG (0.0387). The relationship between the polymorphism of NPY2R gene and the antihypertensive effect of benazepril: (1) there were significant differences in body weight, waist circumference and waist-to-hip ratio among different genotypes (p = 0.0322 卤0.0099 and 0.0108, respectively).
【学位授予单位】：安徽医科大学
【学位级别】：硕士
【学位授予年份】：2005
【分类号】：R181.3
【参考文献】
相关期刊论文 前2条
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2 曾春雨,刘光耀,王旭开,孙久福;老年人收缩期高血压血浆神经肽Y的改变及培哚普利干预的研究[J];中华老年医学杂志;1998年01期
本文编号：2310594
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