郑州市二七区2008～2012年住院手足口病患者病原、临床特征及流行因素调查

发布时间：2018-11-20 12:38

【摘要】：目的:了解手足口病(HFMD)病原、临床特征及其主要流行因素,为科学制定郑州市二七区HFMD的防控措施提供依据。方法:采用RT-PCR方法对河南省郑州市二七区HFMD定点医院2008~2012年住院HFMD患者的粪便标本2 932份进行肠道病毒、肠道病毒71型(EV71)和柯萨奇病毒A16型(CoxA16)检测,并观察其临床特征,分析其主要流行因素。结果:2 932份粪便标本中有2 062份检出肠道病毒,其中748份EV71阳性,527份CoxA16阳性,787份其他肠道病毒阳性。2008、2009、2010、2011、2012年该地区住院HFMD患者病原体构成不全相同(χ2=109.741,P0.001),EV71是2010年HFMD流行的主要病原体。肠道病毒的流行集中于3~7月份,4、5月份达到高峰;93.50%的肠道病毒感染发生于0.5~4.0岁儿童,其感染的型别与患儿的年龄、性别、居住地无关。201例重症HFMD患者中,EV71阳性90例,阳性率高于普通患者,主要表现为脑炎和无菌性脑膜炎,其中2例死亡(死于脑炎和肺水肿或肺出血)。结论:2008~2012年河南省郑州市二七区HFMD流行期间有多种肠道病毒流行,CoxA16和EV71是引起HFMD的主要病原体,EV71是导致重症病例和死亡病例的主要病原体。
[Abstract]:Objective: to understand the etiology, clinical characteristics and main epidemic factors of hand, foot and mouth disease (HFMD) in order to provide scientific basis for the prevention and control of HFMD in Erqi District of Zhengzhou. Methods: RT-PCR was used to detect the enterovirus, enterovirus 71 (EV71) and coxsackie virus A16 (CoxA16) in stool samples from HFMD patients hospitalized in HFMD designated Hospital of Erqi District, Zhengzhou City, Henan Province from 2008 to 2012. The clinical characteristics were observed and the main epidemic factors were analyzed. Results: of the 2 932 fecal specimens, 2 062 were detected enterovirus, of which 748 were EV71 positive, 527 were CoxA16 positive and 787 were positive for other enterovirus. EV71 is the main pathogen of HFMD epidemic in 2010. The prevalence of enterovirus was concentrated in March and July, and reached its peak in April and May. 93.50% of the cases of enterovirus infection occurred in 0. 5 0 years old children. The type of infection was not related to the age, sex and residence of the children. Among 201 cases of severe HFMD, 90 cases were positive for EV71, and the positive rate was higher than that of the normal patients. The main manifestations were encephalitis and aseptic meningitis, 2 of which died of encephalitis and pulmonary edema or pulmonary hemorrhage. Conclusion: during the period of HFMD epidemic in Erqi District of Zhengzhou City, Henan Province from 2008 to 2012, there were many enterovirus epidemics. CoxA16 and EV71 were the main pathogens causing HFMD, and EV71 was the main pathogen leading to severe cases and death cases.
【作者单位】：郑州大学公共卫生学院流行病学教研室;郑州大学第五附属医院感染科;
【基金】：国家自然科学基金资助项目81172740
【分类号】：R181.3

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