乌鲁木齐市2007-2010年度流感病毒病原学监测分析
发布时间：2019-02-19 13:20
【摘要】：目的：探讨乌鲁木齐市流感流行规律,便于做好流行性感冒的预防与控制工作。同时为乌鲁木齐市流感病毒的变异预防控制研究奠定基础。方法：通过中国流感中心流感监测系统,对乌鲁木齐市2007-2010年的流感进行病原学监测。结果：通过对乌鲁木齐市2007～2010年流感监测资料进行分析发现：1、在2007/2008监测年度,共采集流感样病例标本127份,其中检出流感病毒B型(Victoria系) 1株,B型(Yamagata) 6株,检出率为5.51%。在2008/2009监测年度,共采集流感样病例标本203份,其中检出流感病毒全部为B型(Victoria)13株,检出率为6.40%。在2009/2010监测年度,乌鲁木齐市暴发新甲型H1N1疫情,共采集流感样标本1218份,其中检出流感病毒阳性株504株,454株为新甲型H1N1,8株A1(H1N1)亚型株,12株为A3(H3N2),30株B (Victoria),检出率为41.38%；病毒分离率以2009/2010监测年度最高。2、三年度0～19岁的流感病毒株阳性率不同,其中2009/2010年度流感病毒阳性株高于2007/2008,2008/2009年度。2009/2010年度各年龄组比较无统计学差异(χ2=8.895,P=0.113)。通过分别对三个年度不同性别之间的流感病毒阳性率间无统计学差异(P值均大于0.05)。3、通过对三个监测年度流感病毒阳性株时间分布分析,2007/2008年度阳性毒株的检出高峰为2007年11月,2008/2009年度阳性毒株的检出高峰为2008年11月和12月,2009/2010年度阳性毒株的检出高峰为2009年10月、11月和12月。结论：通过流感病毒监测系统对乌鲁木齐市2007-2010监测年度分析发现,乌鲁木齐市流感活动高峰时间为每年的冬季和春季,并且各年度流感流行的优势株也会不停的变化。1、2007/2008年度流感流行的优势株是B型(Yamagata系),2008/2009年度流行的优势株为B型(Victoria系),2009/2010年度因新甲型H1N1的爆发全部转换为新甲型H1N1,但是等疫情过后流感亚型趋近于正常,优势株为B(Victoria)亚型。2、三个年度0～19岁的流感病毒株阳性率不同。三个年度不同性别之间的流感病毒阳性率间无统计学差异。3、乌鲁木齐市从2007年开始流感病毒的优势株为B型,且优势一直并持续至2008/2009年度,B型毒株的流行时间与全国其他地区流行期来临的时间基本一致。4、样本的采集质量严重影响病毒分离率,采集合格的样本是病毒分离的基础；5、乌鲁木齐市流感流行规律与我国北方地区的流感流行规律基本吻合,主要体现在流行类型及优势株转换基本相同,流行高峰时段与北方其他省市基本同步。根据流感毒株变化趋势发现每年引起春季流感暴发的流行株会成为当年冬季流感流行的优势株,因此预测2010～2011年度流感流行优势株可能为B (Victoria)亚型。
[Abstract]:Objective: to probe into the epidemic law of influenza in Urumqi, and to facilitate the prevention and control of influenza. It also lays a foundation for the prevention and control of influenza virus mutation in Urumqi. Methods: the pathogen of Urumqi Influenza in 2007 / 2010 was monitored by China Influenza Center Influenza Surveillance system. Results: based on the analysis of influenza surveillance data from 2007 to 2010 in Urumqi, we found that: 1 in 2007 / 2008 surveillance year, a total of 127 influenza-like cases were collected, of which 1 strain of influenza virus B (Victoria strain) and 6 strains of type B (Yamagata) were detected. The detection rate was 5.51%. In the surveillance year of 2008 / 2009, 203 samples of influenza like cases were collected, of which 13 strains of influenza virus were found to be type B (Victoria), and the detection rate was 6.40%. In the surveillance year of 2009 / 2010, a new type A H1N1 outbreak occurred in Urumqi. A total of 1218 influenza samples were collected, of which 504 were positive for influenza virus, 454 were new A1 (H1N1) subtype, 12 were A3 (H3N2). The positive rate of 30 B (Victoria), strains was 41.38; The virus isolation rate was the highest in 2009 / 2010 surveillance year. 2. The positive rate of influenza virus strain 0 / 19 years old in three years was different. The number of influenza virus positive strains in 2009 / 2010 was higher than that in 2007 / 2008 / 2008 / 2009. There was no significant difference among all age groups in 2009 / 2010 (蠂 ~ 2 / 8.895% P ~ (0.113). There was no significant difference in the positive rate of influenza virus among the three years (P > 0.05). 3. The time distribution of the positive strains of influenza virus was analyzed. The peak of positive strains in 2007 / 2008 was November 2007, the peak of positive strains in 2008 / 2009 was November and December 2008, and the peak of positive strains in 2009 / 2010 was October, November and December 2009. Conclusion: the annual analysis of influenza virus surveillance system in Urumqi from 2007 to 2010 shows that the peak time of influenza activity in Urumqi is winter and spring every year. The dominant strains of influenza epidemic in 2007 / 2008 were type B (Yamagata strain), and the dominant strains in 2008 / 2009 were type B (Victoria strain). In 2009 / 2010, due to the outbreak of new type A H1N1, all of them were transformed into new type A H1N1, but after the outbreak, the influenza subtype approached to normal, the dominant strain was B (Victoria) subtype. 2. The positive rate of influenza virus strains aged 0 or 19 years in three years was different. There is no statistical difference in the positive rate of influenza virus between sexes in three years. 3. In Urumqi, the dominant strain of influenza virus has been type B since 2007, and the dominant strain has continued until 2008 / 2009. The epidemic time of B strain was basically the same as that of other regions in China. 4. The collection quality of samples seriously affected the virus isolation rate, and the collection of qualified samples was the basis of virus isolation. 5. The epidemic pattern of influenza in Urumqi is basically consistent with that of the north of China, which is mainly reflected in the same epidemic type and dominant plant conversion, and the epidemic peak period is basically in sync with other provinces and cities in the north. According to the trend of influenza virus strain, it is found that the epidemic strain that causes spring influenza outbreak will become the dominant strain of winter influenza epidemic in that year, so it is predicted that the dominant influenza epidemic strain in 2010 / 2011 may be B (Victoria) subtype.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R181.3
本文编号：2426535
[Abstract]:Objective: to probe into the epidemic law of influenza in Urumqi, and to facilitate the prevention and control of influenza. It also lays a foundation for the prevention and control of influenza virus mutation in Urumqi. Methods: the pathogen of Urumqi Influenza in 2007 / 2010 was monitored by China Influenza Center Influenza Surveillance system. Results: based on the analysis of influenza surveillance data from 2007 to 2010 in Urumqi, we found that: 1 in 2007 / 2008 surveillance year, a total of 127 influenza-like cases were collected, of which 1 strain of influenza virus B (Victoria strain) and 6 strains of type B (Yamagata) were detected. The detection rate was 5.51%. In the surveillance year of 2008 / 2009, 203 samples of influenza like cases were collected, of which 13 strains of influenza virus were found to be type B (Victoria), and the detection rate was 6.40%. In the surveillance year of 2009 / 2010, a new type A H1N1 outbreak occurred in Urumqi. A total of 1218 influenza samples were collected, of which 504 were positive for influenza virus, 454 were new A1 (H1N1) subtype, 12 were A3 (H3N2). The positive rate of 30 B (Victoria), strains was 41.38; The virus isolation rate was the highest in 2009 / 2010 surveillance year. 2. The positive rate of influenza virus strain 0 / 19 years old in three years was different. The number of influenza virus positive strains in 2009 / 2010 was higher than that in 2007 / 2008 / 2008 / 2009. There was no significant difference among all age groups in 2009 / 2010 (蠂 ~ 2 / 8.895% P ~ (0.113). There was no significant difference in the positive rate of influenza virus among the three years (P > 0.05). 3. The time distribution of the positive strains of influenza virus was analyzed. The peak of positive strains in 2007 / 2008 was November 2007, the peak of positive strains in 2008 / 2009 was November and December 2008, and the peak of positive strains in 2009 / 2010 was October, November and December 2009. Conclusion: the annual analysis of influenza virus surveillance system in Urumqi from 2007 to 2010 shows that the peak time of influenza activity in Urumqi is winter and spring every year. The dominant strains of influenza epidemic in 2007 / 2008 were type B (Yamagata strain), and the dominant strains in 2008 / 2009 were type B (Victoria strain). In 2009 / 2010, due to the outbreak of new type A H1N1, all of them were transformed into new type A H1N1, but after the outbreak, the influenza subtype approached to normal, the dominant strain was B (Victoria) subtype. 2. The positive rate of influenza virus strains aged 0 or 19 years in three years was different. There is no statistical difference in the positive rate of influenza virus between sexes in three years. 3. In Urumqi, the dominant strain of influenza virus has been type B since 2007, and the dominant strain has continued until 2008 / 2009. The epidemic time of B strain was basically the same as that of other regions in China. 4. The collection quality of samples seriously affected the virus isolation rate, and the collection of qualified samples was the basis of virus isolation. 5. The epidemic pattern of influenza in Urumqi is basically consistent with that of the north of China, which is mainly reflected in the same epidemic type and dominant plant conversion, and the epidemic peak period is basically in sync with other provinces and cities in the north. According to the trend of influenza virus strain, it is found that the epidemic strain that causes spring influenza outbreak will become the dominant strain of winter influenza epidemic in that year, so it is predicted that the dominant influenza epidemic strain in 2010 / 2011 may be B (Victoria) subtype.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：R181.3
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