院内感染患者致病菌的流行病学调查及主要致病菌耐药机制的初步探讨
发布时间：2019-02-23 23:47
【摘要】：院内感染是指发生在医院内的一切感染,包括菌血症、肺炎、尿路感染和手术部位的感染等,医院感染不仅影响患者的康复和增加费用,也给国家有限的卫生资源带来巨大的浪费,同时增加了医护人员的压力。随着医学科学的飞速发展,降低院内感染已成为当今研究的新课题。耐药菌株是引发院内感染的主要病原微生物,此类微生物经过抗生素的多次选择性作用,已经形成耐药性很强的菌株,而且长期在医院内流行。吉林大学第一医院是我省最大的综合性教学医院,抗生素使用量大,而且大多数新药又是首先被使用,故该院细菌的耐药问题具有一定的代表性。为此于2003年10月至2004年10月对吉大一院主要临床科室住院感染以及致病菌分布情况和这些科室住院感染主要致病菌的耐药性进行了一年的调查,并利用质粒提取试验和质粒消除试验对主要致病菌的耐药机制予以初步探讨。为吉林大学第一医院住院感染细菌的流行病学及分子流行病学研究提供第一手资料。 本实验的主要工作包括以下几个方面: 一、吉林大学第一医院院内感染流行病学研究 1、部分科室住院患者感染以及致病菌分布情况的调查 2、部分科室感染性疾病主要致病菌的耐药性的调查 二、主要致感染性疾病细菌的耐药机制分析 1、引起吉林大学第一医院院内感染的主要致病菌耐药性R质粒的提 取。 2、R质粒消除实验
[Abstract]:Nosocomial infection refers to all infections occurring in the hospital, including bacteremia, pneumonia, urinary tract infection and surgical site infection. Nosocomial infection not only affects the patient's rehabilitation and increases the cost. It also creates a huge waste of the nation's limited health resources and increases the pressure on health care workers. With the rapid development of medical science, reducing nosocomial infection has become a new research topic. Drug resistant strains are the main pathogenic microorganisms that cause nosocomial infection. After many times of selective action of antibiotics, the resistant strains have been formed and have been prevalent in hospitals for a long time. The first Hospital of Jilin University is the largest comprehensive teaching hospital in our province. The use of antibiotics is large, and most new drugs are first used, so the problem of drug resistance of bacteria in Jilin University is representative. From October 2003 to October 2004, we investigated the main clinical infection and the distribution of pathogenic bacteria and the drug resistance of the main pathogens in the first Hospital of Jida from October 2003 to October 2004. The drug resistance mechanism of main pathogenic bacteria was preliminarily discussed by plasmid extraction test and plasmid elimination test. To provide first-hand data for the epidemiology and molecular epidemiology of infection bacteria in the first Hospital of Jilin University. The main work of this experiment includes the following aspects: 1. The epidemiological study of nosocomial infection in the first Hospital of Jilin University. Investigation of infection and distribution of pathogenic bacteria among inpatients in some departments 2. Investigation of drug resistance of the main pathogens of infectious diseases in some departments. Analysis of drug resistance mechanism of bacteria causing major infectious diseases 1. Extraction of resistant R plasmids of the main pathogenic bacteria caused by nosocomial infection in the first Hospital of Jilin University. Elimination experiment of 2R plasmid
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2005
【分类号】：R181.3
本文编号：2429347
[Abstract]:Nosocomial infection refers to all infections occurring in the hospital, including bacteremia, pneumonia, urinary tract infection and surgical site infection. Nosocomial infection not only affects the patient's rehabilitation and increases the cost. It also creates a huge waste of the nation's limited health resources and increases the pressure on health care workers. With the rapid development of medical science, reducing nosocomial infection has become a new research topic. Drug resistant strains are the main pathogenic microorganisms that cause nosocomial infection. After many times of selective action of antibiotics, the resistant strains have been formed and have been prevalent in hospitals for a long time. The first Hospital of Jilin University is the largest comprehensive teaching hospital in our province. The use of antibiotics is large, and most new drugs are first used, so the problem of drug resistance of bacteria in Jilin University is representative. From October 2003 to October 2004, we investigated the main clinical infection and the distribution of pathogenic bacteria and the drug resistance of the main pathogens in the first Hospital of Jida from October 2003 to October 2004. The drug resistance mechanism of main pathogenic bacteria was preliminarily discussed by plasmid extraction test and plasmid elimination test. To provide first-hand data for the epidemiology and molecular epidemiology of infection bacteria in the first Hospital of Jilin University. The main work of this experiment includes the following aspects: 1. The epidemiological study of nosocomial infection in the first Hospital of Jilin University. Investigation of infection and distribution of pathogenic bacteria among inpatients in some departments 2. Investigation of drug resistance of the main pathogens of infectious diseases in some departments. Analysis of drug resistance mechanism of bacteria causing major infectious diseases 1. Extraction of resistant R plasmids of the main pathogenic bacteria caused by nosocomial infection in the first Hospital of Jilin University. Elimination experiment of 2R plasmid
【学位授予单位】：吉林大学
【学位级别】：硕士
【学位授予年份】：2005
【分类号】：R181.3
【引证文献】
相关期刊论文 前1条
1 韩姗姗;盛英霞;任慧英;;MRSA在欧洲和日本的流行病学及其应对策略[J];中国农学通报;2012年32期
，本文编号：2429347
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