2013-2014年宁波农村地区手足口病病原学流行特征分析
发布时间：2019-04-26 13:28
【摘要】：目的分析2013-2014年宁波农村地区手足口病(HFMD)病原学流行特征及规律,为手足口病的预防控制提供病原学依据。方法选取2013年1月-2014年12月宁波农村地区临床诊断为HFMD的患儿334例为研究对象,采用实时荧光定量PCR方法对研究对象标本进行肠道病毒通用型(EV)、肠道病毒71型(EV71)、柯萨奇病毒A组16型(CoxA16)核酸检测,并运用SPSS19.0进行描述性流行病学分析。结果采集到的334例HFMD病例生物学标本,阳性检出率为73.05%,其中EV71、CoxA16和其他EV比例分别占17.62%、17.62%和64.75%;两年间HFMD病原构成差异有统计学意义(P0.05),EV71在春夏季感染率高,CoxA16在夏秋季感染率高,其他EV四季普遍易感,差异有统计学意义(P0.05);不同性别、职业及5岁人群的HFMD病原构成基本相同,感染各型病原的风险差异无统计学意义;重症病例EV71感染率高于普通病例,EV71感染者重症病例发生率最高,差异均有统计学意义(P0.05)。结论该地区不同特征人群EV71、CoxA16及其他EV的感染率主要受总体优势病原影响。EV71、CoxA16及其他EV的感染流行季节有差异,且病原类型与患儿临床病情轻重程度有关,在HFMD流行季节开展病原监测有助于指导临床治疗,避免不良预后的发生。
[Abstract]:Objective to analyze the epidemic characteristics and regularity of hand, foot and mouth disease (HFMD) in rural areas of Ningbo from 2013 to 2014, so as to provide the etiological basis for the prevention and control of hand, foot and mouth disease (HFMD). Methods A total of 334 children diagnosed as HFMD from January 2013 to December 2014 in rural areas of Ningbo were selected as subjects. Real-time fluorescence quantitative PCR was used to detect enterovirus type (EV), enterovirus 71 (EV71). Coxsackievirus A group 16 (CoxA16) nucleic acid was detected and SPSS19.0 was used for descriptive epidemiological analysis. Results the positive rate of HFMD was 73.05%, among which the proportion of EV71,CoxA16 and other EV was 17.62%, 17.62% and 64.75%, respectively. There was significant difference in the pathogen composition of HFMD between the two years (P0.05), the infection rate of EV71 in spring and summer was high, the infection rate of CoxA16 in summer and autumn was high, the other four seasons of EV were susceptible to infection, the difference was statistically significant (P0.05); There was no significant difference in the risk of infection of HFMD between different sex, occupation and 5-year-old population, but there was no significant difference in the risk of infection among different types of pathogens. The infection rate of EV71 in severe cases was higher than that in common cases, and the incidence of severe cases with EV71 infection was the highest, the difference was statistically significant (P0.05). Conclusion the infection rates of EV71,CoxA16 and other EV in different characteristic population in this area are mainly affected by the overall dominant pathogen. The epidemic seasons of EV 71, CoxA16 and other EV are different, and the pathogen type is related to the severity of the clinical condition of the children. The pathogen monitoring during the epidemic season of HFMD is helpful to guide clinical treatment and avoid the occurrence of bad prognosis.
【作者单位】： 浙江大学公共卫生学院;宁波市鄞州区疾病预防控制中心;宁波市鄞州区邱隘中心卫生院;浙江中医药大学流行病学与卫生统计学教研室;
【基金】：浙江省医药卫生科技基金资助项目(2009A190) 宁波市鄞州区科技局第二批科技计划基金资助项目[(2012)90号]
【分类号】：R725.1;R181.3
，
本文编号：2466105
[Abstract]:Objective to analyze the epidemic characteristics and regularity of hand, foot and mouth disease (HFMD) in rural areas of Ningbo from 2013 to 2014, so as to provide the etiological basis for the prevention and control of hand, foot and mouth disease (HFMD). Methods A total of 334 children diagnosed as HFMD from January 2013 to December 2014 in rural areas of Ningbo were selected as subjects. Real-time fluorescence quantitative PCR was used to detect enterovirus type (EV), enterovirus 71 (EV71). Coxsackievirus A group 16 (CoxA16) nucleic acid was detected and SPSS19.0 was used for descriptive epidemiological analysis. Results the positive rate of HFMD was 73.05%, among which the proportion of EV71,CoxA16 and other EV was 17.62%, 17.62% and 64.75%, respectively. There was significant difference in the pathogen composition of HFMD between the two years (P0.05), the infection rate of EV71 in spring and summer was high, the infection rate of CoxA16 in summer and autumn was high, the other four seasons of EV were susceptible to infection, the difference was statistically significant (P0.05); There was no significant difference in the risk of infection of HFMD between different sex, occupation and 5-year-old population, but there was no significant difference in the risk of infection among different types of pathogens. The infection rate of EV71 in severe cases was higher than that in common cases, and the incidence of severe cases with EV71 infection was the highest, the difference was statistically significant (P0.05). Conclusion the infection rates of EV71,CoxA16 and other EV in different characteristic population in this area are mainly affected by the overall dominant pathogen. The epidemic seasons of EV 71, CoxA16 and other EV are different, and the pathogen type is related to the severity of the clinical condition of the children. The pathogen monitoring during the epidemic season of HFMD is helpful to guide clinical treatment and avoid the occurrence of bad prognosis.
【作者单位】： 浙江大学公共卫生学院;宁波市鄞州区疾病预防控制中心;宁波市鄞州区邱隘中心卫生院;浙江中医药大学流行病学与卫生统计学教研室;
【基金】：浙江省医药卫生科技基金资助项目(2009A190) 宁波市鄞州区科技局第二批科技计划基金资助项目[(2012)90号]
【分类号】：R725.1;R181.3
，
本文编号：2466105
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