天津市滨海新区水痘疫苗免疫效果评价

发布时间：2019-05-14 18:50

【摘要】：目的:开展无明胶冻干型水痘减毒活疫苗保护性效果评价;观察突破病例发生情况,探讨水痘疫苗免疫策略。接种人群为居住在滨海新区的满12月龄~12周岁儿童,已接种过水痘疫苗或已患过水痘的除外。对照人群为环城四区同龄未接种水痘儿童。方法:对目标人群实施疫苗接种。全部接种者观察42 d至2年半后,水痘突破病例发生情况。以观察组和对照组两组对比观察计算水痘疫苗保护率。结果:本次无明胶水痘减毒疫苗突破病例为134例,发生率为0.35%;无明胶水痘减毒疫苗保护率80.92%,与国内外相关报道基本一致。结论:接种疫苗后42 d至2年半内,接种水痘疫苗可有效保护儿童免于发病,同时减轻了儿童患病的痛苦和家庭的经济负担。接种水痘疫苗后仍有突破病例发生,因此要考虑进行二次接种,以进一步观察二次接种后机体产生抗体水平变化及流行病学保护效果。
[Abstract]:Objective: to evaluate the protective effect of live attenuated varicella vaccine without gelatin freeze-drying, to observe the occurrence of breakthrough cases, and to explore the immunization strategy of varicella vaccine. The vaccinated population was children aged 12 months to 12 years old living in Binhai New area, except those who had been vaccinated against varicella or had already suffered from varicella. The control group was children of the same age who were not vaccinated with varicella in the fourth district around the city. Methods: the target population was vaccinated. All vaccinators observed the occurrence of varicella breakthrough after 42 days to 2 and a half years. The protective rate of varicella vaccine was compared between the observation group and the control group. Results: 134 cases of non-gelatin varicella attenuated vaccine broke through, the incidence was 0.35%, and the protective rate of non-gelatin varicella attenuated vaccine was 80.92%, which was basically consistent with the relevant reports at home and abroad. Conclusion: vaccination with varicella vaccine can effectively protect children from onset within 42 days to 2 and a half years after vaccination, and at the same time reduce the suffering of children and the economic burden of their families. There are still breakthrough cases after vaccination with varicella vaccine, so it is necessary to consider secondary vaccination in order to further observe the changes of antibody level and epidemiological protective effect after secondary vaccination.
【作者单位】：天津市滨海新区汉沽疾病预防控制中心;天津市疾病预防控制中心;天津市滨海新区塘沽疾病预防控制中心;天津市滨海新区大港卫生防病站;天津市滨海新区经济技术开发区卫生防病站;
【分类号】：R186

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