系统性红斑狼疮患者医院感染的危险因素分析

发布时间：2019-06-25 12:57

【摘要】：目的探讨系统性红斑狼疮并发医院感染的危险因素,为预防控制医院感染的发生提供参考。方法回顾性分析2011年1月-2012年6月住院的SLE患者,按照是否发生医院感染将其分为感染组和非感染组,比较两组在系统性红斑狼疮疾病活动性指数评分、补体C3水平、浆膜炎情况、白蛋白水平、贫血程度、白细胞减少率、肾功能、激素和免疫抑制剂使用等方面的差异。结果病情中重度活动患者64例中感染34例占53.13%,使用免疫抑制剂治疗患者33例中感染21例占63.64%,与相应对照组比较差异无统计学意义;低C3血症患者70例中感染44例占62.86%,浆膜炎患者52例中感染34例占65.38%,低白蛋白血症患者95例中感染54例占56.84%,中度以上贫血患者47例中感染30例占63.83%,血白细胞减少患者42例中感染27例占64.29%,肾功能不全患者26例中感染20例占76.92%,使用激素治疗患者53例中感染41例占77.36%,与对照组比较差异有统计学意义(P0.05)。结论低C3血症、浆膜炎、低白蛋白血症、中度以上贫血、血白细胞减少、肾功能不全、使用激素为SLE合并医院感染的危险因素,病情活动、使用免疫抑制剂不会增加感染风险。
[Abstract]:Objective to explore the risk factors of systemic lupus erythematosus complicated with hospital infection, and to provide reference for prevention and control of hospital infection. Methods SLE patients hospitalized from January 2011 to June 2012 were divided into infection group and non-infection group according to whether or not hospital infection occurred. The differences in disease activity index score, complement C3 level, seroiditis, albumin level, anemia degree, leukopenia rate, renal function, hormone and immunosuppressant use between the two groups were compared. Results among 64 patients with moderate and severe activity, 34 (53.13%) were infected and 21 (63.64%) were treated with immunosuppressive agents. There was no significant difference between the two groups. Of the 70 patients with hypo-C3, 44 (62.86%) were infected, 34 (65.38%) were seroiditis, 54 (56.84%) were hypoalbuminemia, 30 (63.83%) were moderate anemia, 27 (64.29%) were leukopenia, 20 (76.92%) were renal insufficiency, 30 (63.83%) were moderate anemia, 27 (64.29%) were leukopenia, and 20 (76.92%) were renal insufficiency. Among the 53 patients treated with hormone, 41 cases (77.36%) were infected, which was significantly different from that of the control group (P 0.05). Conclusion hypoC3, seroiditis, hypoalbuminemia, moderate anemia, leukopenia, renal insufficiency, hormone use are the risk factors of SLE complicated with hospital infection, and the activity of the disease and immunosuppressive agents do not increase the risk of infection.
【作者单位】：中山大学附属第一医院医院感染管理科;中山大学附属第一医院呼吸内科;中山大学附属第一医院感染管理科;中山大学附属第一医院风湿内科;
【基金】：广东省科技计划项目(2008A030201029)
【分类号】：R593.241

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