一种酚类复方手消毒凝胶消毒性能研究

发布时间：2019-08-01 11:28

【摘要】：目的研究一种以对氯间二甲苯酚为主要杀菌成分的复方手消毒凝胶的消毒性能,为实际应用提供科学依据。方法采用理化分析、载体定量杀菌试验和动物试验方法,对该复方手消毒凝胶的消毒相关的性能进行了试验观察。结果该复方手消毒凝胶含对氯间二甲苯酚和乙醇分别为质量分数0.274%和58.3%,置37℃温箱内储存90 d,其两种有效成分含量下降率均5.0%。用该复方手消毒凝胶原液作用0.5 min,对载体上金黄色葡萄球菌、大肠杆菌、铜绿假单胞菌及白色念珠菌的杀灭对数值各次均大于3.00。用该复方手消毒凝胶擦拭消毒手1.0 min,对手上自然菌的杀灭对数值各次均值大于1.00。该复方手消毒凝胶的小鼠急性经口毒性LD50值5 000mg/kg(体重),对皮肤无刺激性;小鼠骨髓嗜多染红细胞微核试验为阴性,亚急性经口毒性试验对雌雄SD大鼠最大未观察到有害作用的剂量为1 000 mg/kg。结论该复方手消毒凝胶对细菌繁殖体和真菌具有快速杀灭效果,属实际无毒级物质,对皮肤无刺激性,无致突变作用,性能稳定。
[Abstract]:Objective to study the disinfection performance of a compound hand disinfection gel with p-chloro-m-xylenol as the main bactericidal component, and to provide scientific basis for practical application. Methods Physicochemical analysis, carrier quantitative germicidal test and animal test were used to observe the disinfection related properties of the compound hand disinfection gel. Results the content of p-chloro-m-xylenol and ethanol in the compound hand disinfection gel was 0.274% and 58.3%, respectively, and stored in a temperature box at 37 鈩，

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