一种皮肤消毒剂的杀菌效果及毒性试验研究
发布时间：2019-08-09 07:23
【摘要】：目的观察一种皮肤消毒剂的杀菌效果和毒性。方法采用悬液定量杀菌试验和动物毒性试验,对该皮肤消毒剂的杀菌效果及安全性进行实验室评价。结果该皮肤消毒剂原液对悬液内的金黄色葡萄球菌和铜绿假单胞菌作用0.5 min、1 min、1.5 min,平均杀灭对数值均5;对白色念珠菌作用0.5 min、1 min、1.5 min,平均杀灭对数值均4;用该皮肤消毒剂的原液对30人次皮肤作用1 min,对皮肤自然菌的平均杀灭对数值为2.20(1.53~3.38)。该皮肤消毒剂的小鼠急性经口毒性LD505 000 mg/(kg·bw),其原液对大白兔多次皮肤刺激试验为无刺激性,对小鼠骨髓嗜多染红细胞微核试验结果阴性,对大白兔眼刺激试验为微刺激性,对大白兔一次破损皮肤刺激试验为无刺激性。结论该皮肤消毒剂对细菌繁殖体及真菌具有较好的杀灭效果,毒性低、刺激性小。
[Abstract]:Objective to observe the bactericidal effect and toxicity of a skin disinfectant. Methods the germicidal efficacy and safety of the skin disinfectant were evaluated by suspension quantitative germicidal test and animal toxicity test. Results the average killing logarithm of 0.5 min,1 min,1.5 min, on Staphylococcus aureus and Pseudomonas aeruginosa in suspension and 0.5 min,1 min,1.5 min, on candida albicans was 4, and the average killing logarithm of 1 min, on 30 skin times was 2.20 (1.53 鈮，
本文编号：2524644
[Abstract]:Objective to observe the bactericidal effect and toxicity of a skin disinfectant. Methods the germicidal efficacy and safety of the skin disinfectant were evaluated by suspension quantitative germicidal test and animal toxicity test. Results the average killing logarithm of 0.5 min,1 min,1.5 min, on Staphylococcus aureus and Pseudomonas aeruginosa in suspension and 0.5 min,1 min,1.5 min, on candida albicans was 4, and the average killing logarithm of 1 min, on 30 skin times was 2.20 (1.53 鈮，
本文编号：2524644
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