等比重罗哌卡因用于妊娠高血压综合征产妇剖宫产术麻醉的半数有效剂量

发布时间：2017-12-28 14:24

本文关键词：等比重罗哌卡因用于妊娠高血压综合征产妇剖宫产术麻醉的半数有效剂量　出处：《山西医药杂志》2016年07期 　论文类型：期刊论文

【摘要】：目的确定等比重罗哌卡因蛛网膜下腔阻滞用于妊娠高血压综合征剖宫产术的半数有效剂量(ED50)和95%可信区间(CI),并探讨其安全性。方法择期妊娠高血压综合征剖宫产产妇30例,美国麻醉医师协会(ASA)分级Ⅰ~Ⅱ级;经腰椎2,3间隙行腰硬联合麻醉,蛛网膜下腔注射罗哌卡因,注射时间30s。第1例产妇罗哌卡因剂量为10mg,采用序贯法,根据蛛网膜下腔阻滞是否成功确定下一例产妇的罗哌卡因的用量,相邻剂量梯度为0.5mg。采用Probit analysis法计算罗哌卡因蛛网膜下腔阻滞用于妊娠高血压综合征产妇剖宫产手术的ED50及95%CI。结果罗哌卡因的ED50为6.326mg,95%CI:(0.115,7.016)mg。结论罗哌卡因用于妊娠高血压综合征产妇剖宫产术蛛网膜下腔阻滞的ED50为6.326mg,该剂量适合于妊娠高血压综合征产妇剖宫产术的麻醉。
[Abstract]:Objective to determine the median effective dose (ED50) and 95% confidence interval (CI) of isobaric ropivacaine subarachnoid block for cesarean section of pregnancy induced hypertension, and to explore its safety. Methods sixty hypertension syndrome of pregnancy after cesarean section in 30 cases, American Society of anesthesiologists (ASA) class I or II; after combined spinal epidural anesthesia for lumbar 2,3 clearance, subarachnoid injection of ropivacaine injection time, 30s. The ropivacaine dosage of first cases was 10mg. Sequential method was used to determine the dosage of ropivacaine in the next case based on the success of subarachnoid block. The adjacent dose gradient was 0.5mg. The Probit analysis method was used to calculate the ED50 and 95%CI of ropivacaine subarachnoid block for cesarean section of pregnant women with pregnancy induced hypertension. Results the ED50 of ropivacaine was 6.326mg, 95%CI: (0.115,7.016) mg. Conclusion ropivacaine used for cesarean section of pregnancy induced hypertension is ED50 for subarachnoid block, 6.326mg, which is suitable for cesarean section anesthesia for women with pregnancy induced hypertension syndrome.
【作者单位】：北京市海淀区妇幼保健院麻醉科;
【分类号】：R614
【正文快照】： 妊娠高血压综合征(妊高征),是妊娠期特有疾病,严重影响母婴健康,是孕产妇和围生儿病死率升高的主要原因[1]。腰硬联合椎管内麻醉是妊娠高血压综合征产妇剖宫产术最好的麻醉方法之一,是产妇及新生儿安全的重要保证。罗哌卡因是一种长效酰胺类局部麻醉药,镇痛效果好,肌松作用完

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