围术期辅助供氧治疗对全身麻醉腹部手术患者术后手术部位感染影响的Meta分析

发布时间：2017-12-28 19:30

本文关键词：围术期辅助供氧治疗对全身麻醉腹部手术患者术后手术部位感染影响的Meta分析　出处：《中国循证医学杂志》2016年04期 　论文类型：期刊论文

【摘要】：目的系统评价围术期应用辅助供氧治疗对全身麻醉腹部手术患者术后手术部位感染的影响。方法计算机检索PubMed、EMbase、The Cochrane Library(2015年第2期)、CBM、VIP、WanFang Data和CNKI数据库,搜集围术期辅助供氧治疗与常规氧浓度通气对全身麻醉腹部手术患者术后手术部位感染(SSI)影响的相关随机对照试验(RCT),检索时限均为建库至2015年3月。由两位评价员独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.3软件进行Meta分析。结果共纳入13个RCT,包括3 532例患者。Meta分析结果显示:围术期辅助供氧组术后SSI发生率明显低于对照组[OR=0.68,95%CI(0.47,0.99),P=0.04],但两组在术后肺不张发生率、因手术部位感染需再次手术发生率及术后30天内死亡率方面,差异均无统计学意义(P均0.05)。结论围术期辅助供氧治疗能够降低全身麻醉腹部手术患者术后手术部位感染的发生率,且不增加其他不良事件发生率。受纳入研究数量和质量的限制,上述结论尚需开展更多高质量研究予以验证。
[Abstract]:Objective to evaluate the effect of perioperative use of auxiliary oxygen therapy on postoperative infection in patients undergoing general anesthesia for abdominal surgery. Methods we searched PubMed, EMbase, The Cochrane Library (2015 second), CBM, VIP, WanFang Data and CNKI database, collect the perioperative supplemental oxygen therapy and conventional oxygen concentration ventilation in surgical site infection on general anesthesia patients after abdominal surgery (SSI) randomized controlled trials (RCT), the influence of the retrieval time are up to March 2015. After two evaluators screened the literature independently, extracted the data and evaluated the bias risk of the study, the RevMan 5.3 software was used for Meta analysis. Results a total of 13 RCT were included, including 3532 patients. The results of Meta analysis showed that SSI perioperative supplemental oxygen group was significantly lower than the control group ([OR=0.68,95%CI 0.47,0.99), P=0.04], but the two groups in the postoperative incidence of atelectasis, due to surgical site infection and the incidence of reoperation for postoperative mortality within 30 days, there were no significant differences (P 0.05). Conclusion perioperative adjuvant oxygen therapy can reduce the incidence of surgical site infection after abdominal surgery, and does not increase the incidence of other adverse events. Due to the limitation of the quantity and quality of the study, the above conclusions need to be verified by more high quality research.
【作者单位】：新疆医科大学第一附属医院麻醉科;
【基金】：新疆维吾尔自治区自然科学基金项目(编号:2014211C038)
【分类号】：R614
【正文快照】： 手术部位感染(surgical site infection,SSI)是腹部手术术后最为常见的并发症之一[1],其不仅可导致患者住院时间延长、医疗费用增加,严重情况下甚至可致患者死亡[2]。SSI发生率受手术类型、患者自身状况、术中体温管理、术后镇痛等多方面因素的影响[3-7]。目前,临床通过应用

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