依托咪酯用于麻醉维持对肺癌患者血清炎性因子的影响

发布时间：2018-01-01 19:21

本文关键词：依托咪酯用于麻醉维持对肺癌患者血清炎性因子的影响　出处：《中国胸心血管外科临床杂志》2016年11期 　论文类型：期刊论文

【摘要】：目的探讨依托咪酯用于全身麻醉维持对肺癌患者血清炎性因子及皮质醇的影响。方法将60例择期行肺腺癌切除手术的患者,随机分为两组:丙泊酚靶控输注组[P组,30例,男17例、女13例,年龄(55.0±5.0)岁]和依托咪酯持续输注组[E组,30例,男16例、女14例,年龄(58.0±5.0)岁]。分别于麻醉前(T_0)、术后即刻(T_1)、术后24 h(T_2)及72 h(T_3)抽取静脉血标本,采用酶联免疫法对肿瘤坏死因子(TNF-α)、白介素-6(IL-6)、白介素-10(IL-10)、皮质醇(Cor)进行标测。结果组内比较:两组T_1、T_2、和T_3时点患者血清IL-6、IL-10浓度较T0时点显著升高(P0.01),两组T_1、T_2时点患者血清TNF-α浓度较T0时点显著升高(P0.01)。组间比较:E组IL-10浓度在T_2、T_3时点较P组低(P0.05);Cor浓度E组在T_1时点低于P组(P0.01)。结论依托咪酯用于麻醉维持期间与丙泊酚并无差别,而对皮质醇分泌有一过性抑制。
[Abstract]:Objective to investigate the effect of etomidate on serum inflammatory factors and cortisol in patients with lung cancer. Methods 60 patients undergoing selective resection of lung adenocarcinoma were randomly divided into two groups: target infusion group with propofol. [Group P (n = 30, male 17, female 13, age: 55.0 卤5.0) and continuous etomidate infusion group (n = 30, n = 30, male 17, F = 13, age: 55.0 卤5.0). [In group E, there were 30 cases (male 16, female 14; age 58.0 卤5.0). Venous blood samples were collected 24 hours after operation and 72 hours after operation. TNF- 伪 (interleukin-6) and interleukin-6 (IL-6) were detected by enzyme-linked immunosorbent assay (Elisa). Results: compared with the two groups, serum IL-6 of patients with T _ 1 / T _ (2) and T _ (3) were compared. The concentration of IL-10 was significantly higher than that of T0. The concentration of TNF- 伪 in serum of patients at T2 time point was significantly higher than that at T0 time point, and the concentration of IL-10 in group 1 was significantly higher than that in group T 0. The concentration of IL-10 in group E was lower than that in group P at the time point of T2and T3. The concentration of Cor in group E was lower than that in group P at T1. Conclusion etomidate has no difference with propofol during anesthesia maintenance, but has a temporary inhibition on cortisol secretion.
【作者单位】：天津市胸科医院麻醉科;
【基金】：天津医学会麻醉学分会青年医师科研培育基金(TJMZJJ-2014-01)~~
【分类号】：R614;R734.2
【正文快照】： 依托咪酯用于麻醉维持对肺癌患者血清炎性因子的影响刘家鹏,董伟,王涛,孙朋,于建健,韩建阁天津市胸科医院麻醉科(天津300222)肺部恶性肿瘤是发病率和死亡率较高、预后较差的恶性肿瘤之一,它生长迅速、浸润破坏组织器官并发生远处转移[1]。手术切除是肺部恶性肿瘤的主要治疗方

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