地佐辛预防瑞芬太尼复合麻醉患者术后疼痛的临床研究

发布时间：2018-01-06 08:22

本文关键词：地佐辛预防瑞芬太尼复合麻醉患者术后疼痛的临床研究　出处：《中国医药指南》2014年01期 　论文类型：期刊论文

【摘要】：目的探讨地佐辛预防瑞芬太尼复合麻醉患者术后疼痛的临床有效性与安全性,指导有效安全的术后抑制疼痛用药。方法回顾性分析我院采用瑞芬太尼复合麻醉进行手术的患者120例,根据其在手术结束前30 min内肌内注射不同剂量的地佐辛分为三组:注射0.1、0.2、0.3 mg/kg地佐辛的低剂量组,中剂量组和高剂量组。观察患者术后拔管、意识、呼吸情况,并在不同时间对患者进行疼痛水平测评,结合实际进行对照分析。结果三组患者拔管时间和意识、呼吸恢复时间从低剂量到高剂量组时间逐渐延长,各组间结果都有明显差异(P0.05);低、中、高剂量组患者拔管后不同时间点的VAS评分值均值前一组明显比后两组评分值高(P0.05);三组中仅高剂量组患者出现呼吸抑制的现象,有25例占62.5%(40/75)。结论术前30 min肌内注射中剂量的地佐辛(0.2 mg/kg)能有效的预防瑞芬太尼复合麻醉患者术后疼痛,并且出现呼吸抑制之类的不良反应风险小。
[Abstract]:Objective to investigate the clinical efficacy and safety of dizosin in the prevention of postoperative pain in patients with remifentanil combined anesthesia. Methods 120 patients with remifentanil combined anesthesia were analyzed retrospectively. According to the different doses of dizosin injected intramuscularly 30 min before the end of the operation, they were divided into three groups: the low dose group with 0.1g 0.2g 0.3 mg/kg dizosin. Middle dose group and high dose group. Observe the postoperative extubation, consciousness, respiration, and at different times to the patients pain level, combined with the actual control analysis. Results the three groups of patients extubation time and consciousness. The time of respiratory recovery from low dose to high dose group was prolonged gradually, and the results of each group were significantly different (P 0.05). The mean VAS score of the first group was significantly higher than that of the latter two groups at different time points after extubation in the low, middle and high dose groups (P 0.05). In the three groups, respiratory inhibition was observed only in the high dose group. There were 25 cases (62.5% 40 / 75). Conclusion Intramuscular injection of dizosinone 0.2 mg / kg 30 min before operation is an intramuscular injection of dizosinone at a moderate dose of 0.2 mg / kg. It can effectively prevent postoperative pain in patients with remifentanil combined anesthesia. And the risk of adverse reactions such as respiratory suppression is low.
【作者单位】：河北省邢台市人民医院麻醉科;
【分类号】：R614
【正文快照】： 目前手术室的复合麻醉通常采用瑞芬太尼进行,该药麻醉效率高,镇痛效果好,很少出现药物蓄积等不良反应,患者术后恢复良好,但是临床证实该药可能引起不同程度的痛觉过敏现象。有研究报道,手术中合理运用地佐辛能够获得抑制复合麻醉后疼痛反应的效果[1],减轻患者的痛苦。我院就地

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