七氟烷和丙泊酚诱导对预防芬太尼诱发呛咳反应的作用比较
发布时间:2018-01-16 01:34
本文关键词:七氟烷和丙泊酚诱导对预防芬太尼诱发呛咳反应的作用比较 出处:《南华大学》2014年硕士论文 论文类型:学位论文
【摘要】:目的观察与比较七氟烷和丙泊酚全麻诱导预防芬太尼诱发呛咳反应的效果及对诱导期血流动力学的影响。 方法选取ASAI-II级,年龄20-60岁,体重40-80kg的择期手术患者60例,随机分为七氟烷诱导组(S组)和丙泊酚诱导组(P组),每组30例。S组用潮气量法行吸入麻醉诱导。P组用丙泊酚靶控输注(TCI)行静脉麻醉诱导。当两组病人意识丧失,呼之不应,睫毛反射消失,脑电双频指数(BIS)值介于40-60时,均从外周肘静脉单向静脉注射芬太尼原液5ug/kg,,注射时间为5s。观察静注芬太尼后1min内呛咳反应发生的有无及其严重程度,严重程度评分标准为:无呛咳(0次),轻度呛咳(1-2次),中度呛咳(3-4次),重度呛咳(≥5次)。观察并记录麻醉诱导前(T0),静注芬太尼前(T1),静注芬太尼后1分钟(T2),及插管后1分钟(T3)的血压(BP)、心率(HR)值来比较两种麻醉诱导方法对诱导期血流动力学的影响。 结果1:两组患者在年龄、性别、体重、基础血压和基础心率等方面无统计学差异(P㧐0.05)。 2:S组呛咳反应的发生率为6.7%,P组呛咳反应的发生率为43.3%(P<0.01)。S组呛咳反应的严重程度明显低于P组(P<0.01)。 3:两组患者血流动力学变化比较和T0比较,S组血压在T1、T2下降,在T3血压上升(P<0.05),P组血压在T1、T2下降,在T3血压上升(P<0.05);S组心率在T1、T2变化无统计学差异,在T3增快(P<0.05),P组心率在T1、T2、T3增快(P<0.05)。组间比较, P组血压在T1低于S组,P组心率在T1、T2、T3高于S组,具有统计学差异(P<0.05)。 结论七氟烷诱导可显著降低芬太尼诱发呛咳反应的发生率及严重程度,能更好地维持诱导期血流动力学的稳定。
[Abstract]:Objective to observe and compare the effects of sevoflurane and propofol on preventing cough induced by fentanyl and hemodynamics during induction. Methods Sixty ASAI-II patients aged 20-60 years and weighing 40-80kg were randomly divided into sevoflurane induced group (S) and propofol induced group (P). 30 cases in group S were induced by inhalation anesthesia with tidal volume method. Group P was induced by intravenous anesthesia with target controlled infusion of propofol (TCI). When the patients in both groups lost consciousness and exhaled, the eyelash reflex disappeared. When the BIS value of EEG was between 40 and 60, fentanyl was injected into the cubital vein in one direction (5ugr / kg). The time of injection was 5 s. The severity of cough reaction within 1 min after intravenous injection of fentanyl was observed. The score of severity was 0 times without choking cough and 1-2 times with mild cough). Three to four times of moderate choking cough and severe choking cough (鈮
本文编号:1431001
本文链接:https://www.wllwen.com/yixuelunwen/mazuiyixuelunwen/1431001.html
最近更新
教材专著