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右美托嘧啶对TURBT手术病人麻醉苏醒期躁动的影响

发布时间:2018-01-16 02:11

  本文关键词:右美托嘧啶对TURBT手术病人麻醉苏醒期躁动的影响 出处:《青岛大学》2014年硕士论文 论文类型:学位论文


  更多相关文章: 躁动 麻醉苏醒期 右美托嘧啶 血流动力学


【摘要】:目的:观察右美托咪定对经尿道膀胱肿瘤电切(TURBT)手术病人麻醉苏醒期躁动的影响。 方法:将60例行TURBT手术的患者随机分为右美托咪定组(D组)和安慰剂组(C组),每组30例,两组均采用全凭静脉麻醉。在麻醉诱导前10min,D组泵注右美托咪定0.5μ g/kg,C组同样方式泵注等容量的生理盐水,分别记录To(入室后5min)、T,(麻醉诱导后)、T2(膀胱镜进镜后)、T3(手术开始后15min)、T4(喉罩拔出后)各时间点患者的HR、MAP数值及术毕病人恢复情况(首次自主呼吸时间,拔管时间,躁动分级及发生率,以及恶心、呕吐、嗜睡、呼吸抑制等不良时间的发生率)。 结果:D组T1时间点MAP、HR值与C组比较无明显差异(P0.05),T2,T3,T4时间点MAP、HR值与C组比较有明显差异(P0.05)。D组的首次自主呼吸及拔管时间较C组比较均无统计学差异(P0.05);D组躁动分级及发生率明显低于C组(P0.05);恶心、呕吐、呼吸抑制及嗜睡等不良事件发生率无有显著差异(P0.05)。 结论:麻醉诱导前10分钟泵注右美托咪定0.5μ g/kg,能有效降低TURBT手术患者血流动力学的波动,减轻病人术后躁动,对病人的苏醒时间及拔管时间无明显影响,且对苏醒期不良事件的发生无明显影响,有助于提高麻醉的安全性。
[Abstract]:Objective: To observe the effect of dexmedetomidin on the restlessness of the patients undergoing transurethral resection of bladder tumor (TURBT).
Methods: 60 cases of TURBT were randomly divided into dexmedetomidine group (D group) and placebo group (C group), 30 cases in each group, two groups were treated with intravenous anesthesia. In 10min before induction of anesthesia, group D infusion of dexmedetomidine 0.5 g/kg normal saline, C group the same way infusion volume were recorded, To (5min, T, after the burglary) (after induction of anesthesia (cystoscope), T2 T3 (in the mirror), after the start of surgery, T4 (15min) after pulling out the laryngeal mask) at each time point in patients with HR, MAP value and postoperative patients recovery the situation (for the first time of spontaneous breathing time, extubation time, and the incidence of restlessness, nausea and vomiting, lethargy, respiratory depression and other adverse time incidence).
Results: in group D, T1 time point MAP, HR values with no significant difference between the C group (P0.05), T2, T3, T4, MAP time point, HR value had significant difference compared with group C (P0.05).D group for the first time of spontaneous breathing and extubation time compared with the C group had no statistical difference (P0.05) D; group of restlessness and was significantly lower than the C group (P0.05); the incidence of nausea, vomiting, respiratory depression and lethargy and other adverse events without significant difference (P0.05).
Conclusion: 10 minutes before anesthesia, infusion of dexmedetomidine 0.5 g/kg TURBT patients can effectively reduce hemodynamic fluctuations, reduce postoperative restlessness, recovery time and pull on the patient's time had no obvious effect, and had no significant effect on the occurrence of adverse events in the recovery period, help to improve safety the anesthetic.

【学位授予单位】:青岛大学
【学位级别】:硕士
【学位授予年份】:2014
【分类号】:R614

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