基于3.0 T磁共振成像系统初步观察WHBE兔脑部形态解剖结构

发布时间：2018-01-26 09:19

本文关键词： 磁共振成像 WHBE兔脑解剖结构　出处：《中国实验动物学报》2017年04期 　论文类型：期刊论文

【摘要】：目的基于3.0 T磁共振成像(MRI)技术,活体观察WHBE兔脑部形态解剖结构,累积WHBE兔脑的影像学基本生物学数据,为进一步拓宽WHBE兔的应用提供背景资料。方法成年雄性WHBE兔9只,用3%戊巴比妥钠溶液静脉注射麻醉,行3.0 T MRI加兔脑专用线圈常规横断面和矢状面扫描,并测量分析脑部的各种结构大小。结果 MRI扫描可成功获得活体WHBE兔脑矢状面和横断面T2WI或T1WI图像,可完整清晰地观察到活体WHBE兔的嗅球、大脑、小脑和垂体等基本结构,并发现了4只兔脑T2WI中左右两侧颞叶海马区高信号,相应区域在T1WI出现低信号外,其余均无异常。同时,获得了额叶、海马、大脑、侧脑室、垂体等相关解剖结构的参考值。结论采用3.0 T磁共振成像系统加上兔脑专用线圈,可以清晰地观察到WHBE兔脑部的各种形态解剖结构,并初步建立了WBHE兔脑影像学基本数据。
[Abstract]:Objective to observe the morphologic and anatomical structure of the brain of WHBE rabbits in vivo and to accumulate the basic imaging biological data of the brain of WHBE rabbits based on 3.0T magnetic resonance imaging (MRI) technique. Methods Nine adult male WHBE rabbits were anesthetized with 3% pentobarbital sodium solution. The normal transverse and sagittal scans were performed with 3. 0 T MRI and rabbit brain special coil. Results the sagittal and cross-sectional T _ 2WI or T _ 1WI images of the brain in vivo WHBE rabbits could be successfully obtained by MRI scanning. The basic structures of olfactory bulb, cerebellum, cerebellum and pituitary gland were observed completely and clearly in living WHBE rabbits, and hyperintense signals were found in the left and right temporal lobe hippocampal area of 4 rabbits on T2WI. There were no abnormalities in the other regions except hypointensity on T1WI. At the same time, frontal lobe, hippocampus, brain and lateral ventricle were obtained. Conclusion with 3.0T magnetic resonance imaging system and special coil of rabbit brain, all kinds of anatomical structures of WHBE rabbit's brain can be clearly observed. The basic imaging data of WBHE rabbit brain were established.
【作者单位】：浙江中医药大学动物实验研究中心/比较医学研究所;浙江中医药大学附属第三医院;浙江中医药大学附属第一医院;
【基金】：浙江省科技厅公益性项目(2016C37092) 浙江省医药卫生科研基金项目(2017KY123) 浙江中医药大学比较医学创新团队(XTD201301);浙江中医药大学校级科研基金项目(2017ZZ01)
【分类号】：R445.2
【正文快照】： Preliminary observation of the anatomical structures of the brain in WHBErabbits by 3.0 T magnetic resonance imaging systemPAN Yong-ming1,JIN Ping2,XU Jian-qin1,LIU Jun-ping1,CAI Zhao-wei1,XU Mao-sheng3,CHEN Min-li1*(1.Laboratory Animal Research Center/C

【相似文献】