顺式阿曲库铵在小儿全身麻醉中对气道功能的影响

发布时间：2018-01-26 15:01

本文关键词： 顺式阿曲库铵阿曲库铵 P_(ET)CO_ P-PEAK 听诊呼吸音　出处：《现代生物医学进展》2016年16期 　论文类型：期刊论文

【摘要】：目的:比较顺式阿曲库铵和阿曲库铵在小儿全麻中对气道功能的影响。方法:选取72名3-9岁患儿,男42例,女30例,采用随机表法将其分为观察组和对照组,每组36例。两组麻醉诱导都采用异丙酚,芬太尼,咪达唑仑。观察组使用顺式阿曲库铵0.15mg/kg,对照组组阿曲库铵0.5 mg/kg,比较两组小儿在插管后5 min、10 min、15 min、20 min患儿P_(ET)CO_2、P-PEAK、听诊呼吸音(粗、细湿Up音)、SPO_2变化四项指标来研究顺式阿曲库铵和阿曲库铵对呼吸系统的影响。结果:观察组注药后5 min、10 min、15 min、20 min时间点P_(ET)CO_2,P-PEAK变化趋势不明显,听诊呼吸音、SPO_2无明显变化(P0.05)。对照组在注药后的4个时间段P_(ET)CO_2、P-PEAK、听诊呼吸音、SPO_2有显著变化,随时间延长,P_(ET)CO_2,P-PEAK有明显增高,SPO_2逐渐下降情况(P0.05)。观察组和对照组相比,5 min、10 min、15 min、20 min各时间点观察组SPO_2高于对照组,PETCO_2、P-PEAK明显低于对照组,Up音发生的概率低于对照组,各时间点各项指标比较差异有统计学意义(P0.05)。结论:顺式阿曲库铵术中对小儿气道功能影响较小,肌松作用理想,可广泛应用于小儿临床麻醉。
[Abstract]:Objective: to compare the effects of cis-atracurium and atracurium on airway function in children under general anesthesia. Methods: 72 children aged 3-9 years, 42 males and 30 females were selected. They were randomly divided into observation group and control group with 36 cases in each group. Propofol, fentanyl and midazolam were used for anesthesia induction in both groups, and cisatracurium 0.15 mg / kg was used in observation group. In the control group, atracurium 0.5 mg / kg was compared between the two groups at 5 minutes, 10 minutes, 15 minutes and 20 min after intubation. P-PEAK, auscultation breath tone (coarse, thin wet up tone). The effects of cis-atracurium and atracurium on respiratory system were studied by four indexes of SPO_2 changes. Results: the observation group was treated with cis-atracurium and atracurium for 5 minutes, 10 minutes and 15 min after injection. At 20 min time point, the change trend of P-PEAK was not obvious, and the auscultation breath tone was not obvious. There was no significant change in SPO_2 (P 0.05). In the control group, there was a significant change in the number of cases in the control group during the four time periods after injection. There was a significant change in the auscultation breath tone and SPO2 in the control group. There was a significant increase in P-PEAK with the prolongation of time. The P0.05 min was gradually decreased in the observation group compared with the control group. The SPO_2 of the observation group was significantly higher than that of the control group at each time point of 10 minutes and 15 minutes and 20 min. The P-PEAK of the observation group was significantly lower than that of the control group. The probability of up sound occurrence was lower than that of the control group, and the difference of the indexes at each time point was statistically significant (P 0.05). Conclusion: cis atracurium has little effect on the airway function of children, and the effect of muscle relaxation is ideal. It can be widely used in pediatric clinical anesthesia.
【作者单位】：武汉大学中南医院麻醉科;襄阳市中心医院北院麻醉科;
【基金】：卫生部医药卫生科技发展研究中心课题基金(W2011GJ13)
【分类号】：R726.1
【正文快照】： Chinese Library Classification(CLC):R614 Document code:AArticle ID:1673-6273(2016)16-3055-03前言现代麻醉学全麻药物中对肌松药要求起效迅速,作用强,代谢迅速,无蓄积,对心血管,呼吸系统影响小。顺式阿曲库铵具有不释放组胺,对心血管影响小,无蓄积作用,代谢产物无毒性及

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