清醒与麻醉状态下大鼠脑电复杂度特征的比较

发布时间：2018-02-03 04:57

本文关键词： 麻醉脑电复杂度样本熵分形维数线性动力系统　出处：《临床麻醉学杂志》2017年01期 　论文类型：期刊论文

【摘要】：目的通过对脑电复杂度样本熵(SampEn)和分形维数(FD)分析,比较清醒和不同麻醉状态下大鼠脑电复杂度特征。方法 SD大鼠16只,每只大鼠先后两次腹腔注射氨基甲酸乙酯(首次500mg/kg、1h后800mg/kg),采集大鼠清醒状态(W段)、浅麻醉状态(LA段)、深麻醉状态(HA段)头皮脑电(EEG),采用MATLAB软件计算EEG信号复杂度的SampEn和FD值,并对全过程的特征值进行线性动力系统(LDS)去噪和各状态下特征值做统计学分析。结果大鼠从清醒到浅麻醉、深麻醉过程中SampEn、FD值逐渐下降。W段的SampEn值与FD值(4.049±0.190和9.299±0.195)明显高于LA段(3.248±0.175和8.528±0.156)和HA段(2.978±0.123和8.213±0.128)(P0.05),HA段的SampEn值与FD值明显低于LA段(P0.05)。结论EEG的SampEn与FD值可作为麻醉深度监测的特征量。
[Abstract]:Objective to compare the characteristics of EEG complexity in awake and anesthetized rats by analyzing the EEG complexity sample entropy and fractal dimension FD.Methods Sixteen SD rats were used. Each rat received intraperitoneal injection of ethyl carbamate twice (800 mg 路kg ~ (-1) h after the first 500 mg 路kg ~ (-1) h). MATLAB software was used to calculate the SampEn and FD values of EEG signal complexity. The characteristic values of the whole process were analyzed by linear dynamic system (LDSs) denoising and the eigenvalues of each state were analyzed statistically. Results the rats were anesthetized from awake to shallow and SampEn was used in deep anesthesia. The SampEn value and FD value of FD decreased gradually. W, 4.049 卤0.190 and 9.299 卤0.195, respectively, which were significantly higher than those of LA (P < 0.05). 3.248 卤0.175 and 8.528 卤0.156) and HA segment 2.978 卤0.123 and 8.213 卤0.128 P0.05). The SampEn and FD values of HA segment were significantly lower than those of LA segment P0.05.Conclusion the SampEn and FD values of EEG can be used as characteristic quantities of depth monitoring of anesthesia.
【作者单位】：皖南医学院医学工程教研室;
【基金】：2014年皖南医学院中青年科研基金项目(WK201419) 2016年高校优秀中青年骨干人才国内外访学研修重点项目(gxfxZD2016156)
【分类号】：R614
【正文快照】： 脑电信号(EEG)是大脑中枢神经系统电活动在头皮的总体表现,可直接反映脑活动、脑功能的基本状况。EEG是监测麻醉状态最直接的生理参数[1]。基于EEG开发出的麻醉深度监测仪器有脑电功率谱(SEF)、脑电双频指数(BIS)、脑电熵指数(Entropy)、脑电Narcotrend(NT)、听觉诱发电位(AEP

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