不同缓冲盐系对噻环乙胺麻醉效果影响和刺激性比较

发布时间：2018-02-08 21:50

本文关键词： 缓冲盐溶液噻环乙胺麻醉刺激　出处：《畜牧与兽医》2015年02期 　论文类型：期刊论文

【摘要】：将噻环乙胺加入不同的缓冲盐体系(DZ组生理盐水、LS组磷酸盐缓冲液、JS组枸橼酸盐缓冲液、BL组巴比妥-氯化钠缓冲液)配制成注射剂,选用小鼠进行麻醉试验,用家兔实施刺激性试验,探讨缓冲盐体系对麻醉效果和刺激性的影响。结果显示:噻环乙胺配合BL组缓冲液较配合DZ、LS、JS组缓冲液制成的注射液在小鼠麻醉前期、中期,镇静、肌松、镇痛效果明显优于其他3组(P0.05)。在麻醉后期4组在镇痛和肌松方面虽无明显的差异(P0.05),但BL组在镇静方面明显优于其他3组(P0.05)。在4组进行缓冲盐体系刺激性比较试验中,肌注局部刺激性试验4组均符合注射规定,但在滴眼局部刺激性试验中LS、JS组出现了轻微刺激。
[Abstract]:The injection of thiacycloethylamine was prepared by adding thiacycloethylamine into different buffer salt systems. The mice were anesthetized with normal saline and LS group phosphate buffer solution and JS group citrate buffer solution or BL group barbito-sodium chloride buffer solution. The effects of buffer salt system on anesthetic effect and irritation were studied in rabbits. The results showed that the injection of thiacycloethylamine combined with BL group was more effective than that of DZL LSN JS group in the early, middle and middle stages of anesthesia. The effect of muscle relaxation and analgesia was significantly better than that of the other three groups (P 0.05). Although there was no significant difference in analgesia and muscle relaxation between the four groups at the later stage of anesthesia, BL group was obviously superior to the other three groups in sedation. The local irritation test of intramuscular injection all met the requirement of injection, but in the local irritation test of dropping eyes, there was slight stimulation in the LSN JS group.
【作者单位】：东北农业大学动物医学院;
【基金】：国家自然科学基金项目(31001092) 高等学校博士学科点专项科研基金项目(20102325120016) 黑龙江省教育厅科学技术研究项目(12521003) 东北农业大学大学生创新创业训练计划项目(2013026)
【分类号】：S859.79

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