地佐辛预防镇痛在二尖瓣置换术中的应用分析

发布时间：2018-02-09 06:21

本文关键词： 地佐辛二尖瓣置换术脑血红素氧合酶-　出处：《重庆医学》2017年13期 　论文类型：期刊论文

【摘要】：目的探讨地佐辛预防镇痛对心脏二尖瓣置换术患者麻醉质量及血清脑血红素氧合酶-1(HO-1)的影响。方法选取2013年2月至2015年4月该院拟行全身麻醉体外循环下二尖瓣置换术患者105例,分为空白对照组、对照组和试验组,每组各35例。试验组麻醉诱导前30min给予地佐辛0.15mg/kg,对照组给予吗啡0.15mg/kg,空白对照组给予0.15mg/kg生理盐水;对比3组麻醉前后心率(HR)、平均动脉压(MAP)变化,HO-1水平改变,VAS评分,治疗不良反应情况。结果 T1时刻对照组及空白对照组HR和MAP显著低于试验组(P0.05),T2、T3、T4时刻对照组及空白对照组HR和MAP高于试验组(P0.05);试验组患者在T3、T6、T7时刻OH-1升高比对照组更加显著(P0.05);试验组患者各时刻VAS评分明显低于观察组(P0.05);试验组不良反应明显较小(P0.05)。结论地佐辛预防镇痛对心脏二尖瓣置换术患者镇痛效果良好,可以稳定维持围麻醉期循环血流动力学,提高HO-1水平,降低不良反应。
[Abstract]:Objective to investigate the effect of dizosin preventive analgesia on the quality of anesthesia and serum heme oxygenase-1 (HO-1) in patients undergoing cardiac mitral valve replacement. Methods from February 2013 to April 2015, the mitral valve under cardiopulmonary bypass under general anesthesia in our hospital was selected. 105 patients underwent replacement, The experimental group was given dizosin 0.15 mg / kg 30 minutes before anesthesia induction, the control group was given morphine 0.15 mg / kg, and the blank control group was given 0.15 mg / kg physiological saline. The changes of heart rate and mean arterial pressure (MAPP) before and after anesthesia were compared, and the changes of HO-1 level and VAS score were compared among the three groups before and after anesthesia. Results HR and MAP of the control group and the blank control group were significantly lower than that of the control group and the blank control group at T _ 1 and T _ 3 / T _ 4 time, respectively. The HR and MAP of the control group and the blank control group were higher than those of the test group at T _ 3, T _ 6T _ 7 and T _ 3 / T _ 6 / T _ 7, respectively, and the level of OH-1 in the trial group was significantly higher than that in the control group. The VAS score of the patients in the test group was significantly lower than that in the observation group at every time, and the adverse reaction in the experimental group was significantly smaller than that in the control group. Conclusion the analgesic effect of dizoxin on the patients undergoing mitral valve replacement is good. It can maintain circulatory hemodynamics, increase the level of HO-1 and reduce adverse reactions.
【作者单位】：山东省莱芜市妇幼保健院麻醉科;
【分类号】：R614

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