氟比洛芬酯用于骨科手术后躁动的临床研究

发布时间：2018-02-10 00:19

本文关键词： 氟比洛芬酯地佐辛术后躁动骨科手术　出处：《中国临床药理学杂志》2015年10期 　论文类型：期刊论文

【摘要】：目的评价氟比洛芬酯与地佐辛预防骨科手术后躁动的疗效及安全性。方法 90例美国麻醉医师协会分级标准(ASA)Ⅰ~Ⅱ级择期进行骨科全麻手术患者随机分为氟比洛芬酯(A组),地佐辛组(B组),对照组(C组),每组各30例,术中给予相同的麻醉诱导和维持方案,手术结束前15 min,A组静脉注射比洛芬酯予1 mg·kg-1,B组静脉注射地佐辛10 mg,C组给予0.9%Na Cl溶液2m L。记录每组患者的拔管时间,躁动评分及躁动发生事件,拔管后5 min疼痛评分,拔管前后的平均动脉压、心率及术后不良反应发生率。结果 A,B组的躁动发生率、拔管后5 min疼痛评分均显著低于C组(P0.05),但B组的恶心、呕吐等不良反应发生率显著高于A,C组(P0.05)。结论手术结束前15 min,骨科全麻手术患者静脉滴注氟比洛芬酯1 mg·kg-1可有效减少术后躁动的发生率,且术后不良反应发生率低。
[Abstract]:Objective to evaluate the efficacy and safety of flurbiprofen and dizosin in preventing restlessness after orthopedic surgery. There were 30 cases in each group, 30 cases in group A, 30 cases in group A, 30 cases in group B, and 30 cases in group C in control group. The same anesthetic induction and maintenance regimen was given during the operation, and the extubation time of each group was recorded 15 minutes before the end of the operation by intravenous injection of biprofen ester 1 mg 路kg -1 of dizoxin 10 mg / L in group C with 0.9 mg / g sodium chloride solution (2m L). Restlessness score, restlessness events, pain score 5 min after extubation, mean arterial pressure, heart rate and incidence of adverse reactions after extubation. The pain scores at 5 min after extubation were significantly lower than those in group C (P 0.05), but nausea in group B was significantly lower than that in group C (P 0.05). The incidence of adverse reactions such as vomiting was significantly higher in group A than in group A (P 0.05). Conclusion intravenous infusion of flurbiprofen (1 mg 路kg-1) in orthopedic general anesthesia can effectively reduce the incidence of postoperative restlessness 15 min before the end of the operation, and the incidence of postoperative adverse reactions is low.
【作者单位】：北京市怀柔区中医医院麻醉科;
【分类号】：R614

【参考文献】