异氟醚和七氟醚对肺癌根治术患者血清E-selectin、ICAM-1、MMP-2、MMP-9表达的影响

发布时间：2018-02-16 21:01

本文关键词： 吸入麻醉药肺肿瘤黏附分子基质蛋白金属酶　出处：《临床麻醉学杂志》2015年03期 　论文类型：期刊论文

【摘要】：目的评价异氟醚和七氟醚吸入麻醉对肺癌根治术患者血清E-选择素(E-selectin)、内皮细胞间黏附分子(ICAM)-1、基质金属蛋白酶(MMP)-2、MMP-9浓度变化的影响。方法择期行肺癌根治术患者60例,年龄43~68岁,ASAⅠ或Ⅱ级。采用随机数字表法,将患者随机均分为两组:异氟醚(I组)和七氟醚组(S组)。两组患者气管插管后吸入1.7%~2.3%异氟醚或2.5%~3.4%七氟醚,维持I组异氟醚呼气末浓度为1.5~2.0 MAC、S组七氟醚呼气末浓度维持在1.5~2.0 MAC至术毕。于麻醉诱导前5min(T0)、手术开始后1h(T1)、手术开始后2h(T2)和术后1h(T3)时采集静脉血样,酶联免疫吸附法测定血清E-selectin、ICAM-1、MMP-2、MMP-9表达。结果与T0时比较,T1~T3时I组血清E-selectin、ICAM-1、MMP-2、MMP-9表达明显增加(P0.05),T2、T3时S组血清E-selectin、ICAM-1、MMP-2、MMP-9表达明显降低(P0.05)。T1~T3时S组血清E-selectin、ICAM-1、MMP-2、MMP-9表达明显低于I组(P0.05)。结论七氟醚能抑制肺癌根治术患者血清E-selectin、ICAM-1、MMP-2、MMP-9的表达。
[Abstract]:Objective to evaluate the effects of inhalation anesthesia of isoflurane and sevoflurane on the changes of serum E-selectin, intercellular adhesion molecule (ICAM-1) and matrix metalloproteinase (MMP-2MMP) 9 in patients with lung cancer undergoing radical resection of lung cancer. The patients were randomly divided into two groups: isoflurane group I) and sevoflurane group S, who inhaled 1.7% isoflurane or 2.5% sevoflurane after tracheal intubation. The end-expiratory concentration of isoflurane in group I was maintained at 1.5 ~ 2.0 MAC until the end of operation. Venous blood samples were collected 5 minutes before anesthesia induction, 1 hour after operation, 2 hours after operation and 1 hour after operation. Results compared with T0, the expression of MMP-9 in serum E-selectinus ICAM-1 and MMP-2MMP 9 in group I was significantly higher than that in group I. conclusion the expression of MMP-9 in serum of group S is significantly lower than that of group I. conclusion the expression of MMP-9 in serum of group S is significantly lower than that of group I. conclusion the expression of MMP-9 in group S is significantly lower than that in group I. conclusion the expression of MMP-9 in serum of group S is significantly lower than that of group I. conclusion the expression of MMP-9 in serum of group S is significantly lower than that of group I. conclusion the expression of MMP-9 in serum of group S is significantly lower than that of group I. conclusion the expression of MMP-9 in serum of group S is significantly lower than that of group I. conclusion the expression of MMP-9 in serum of group S is significantly lower than that of group I. To inhibit the expression of MMP-9 in serum of patients undergoing radical resection of lung cancer.
【作者单位】：天津市第二人民医院麻醉科;
【分类号】：R614;R734.2

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