巴马小型猪动物模型在医学领域的研究进展

发布时间：2018-02-20 00:45

本文关键词： 巴马小型猪动物模型医学领域　出处：《中国畜牧兽医》2017年04期 　论文类型：期刊论文

【摘要】：巴马小型猪是中国原产地闭锁繁殖的优质品种,具有遗传稳定性、理想的毛色分布、体型小、多产性、饲养要求低、抗病力强等优势,且在生理学、解剖结构、药物代谢、生化指标和疾病发生机制等方面与人类相似,已用于心血管、皮肤整形、内分泌及代谢、消化、口腔医学、异种移植、中医、麻醉学、神经系统等广泛医学领域的研究,建立了心肌缺血、冠脉微栓塞、卵圆孔未闭、动脉粥样硬化、皮肤创伤、经皮给药、代谢综合征、糖尿病及其并发症、梗阻性黄疸、慢性胰腺炎、肝硬化、肝脏射频消融、牙周组织炎症、下颌骨缺损、异种器官/细胞移植、中医征候、手术麻醉、脑缺血、支架植入、休克等一系列类似于人类疾病的动物模型,表明巴马小型猪作为理想的试验动物在生物医学研究中具有广阔的应用前景。作者综述了巴马小型猪作为试验动物在各医学领域的应用进展,了解现有巴马小型猪疾病模型的种类、构建方法及病理特征,有助于进一步探索具体的病因、发病机制、并发症和防制手段等,为拓展研究范围、提高医学水平奠定了科学基础。
[Abstract]:Bama miniature pig is a high quality breed of atresia breeding in China. It has the advantages of genetic stability, ideal color distribution, small size, high productivity, low breeding requirement, strong disease resistance, and has advantages in physiology, anatomical structure, drug metabolism, etc. Biochemical indicators and disease mechanisms are similar to those of human beings and have been used in the research of cardiovascular, skin plastic, endocrine and metabolism, digestion, stomatology, xenotransplantation, traditional Chinese medicine, anesthesiology, nervous system, and so on. Myocardial ischemia, coronary microembolization, patent foramen ovale, atherosclerosis, skin trauma, percutaneous administration, metabolic syndrome, diabetes mellitus and its complications, obstructive jaundice, chronic pancreatitis, liver cirrhosis, liver radiofrequency ablation, Periodontitis, mandibular defects, xenogeneic organ / cell transplantation, TCM signs, surgical anesthesia, cerebral ischemia, stent implantation, shock, and a series of animal models similar to human diseases. The results show that the Bama miniature pig has a broad application prospect in biomedical research as an ideal experimental animal. The authors review the application of Bama miniature pig as an experimental animal in various medical fields. Understanding the types, construction methods and pathological features of the existing Bama miniature pig disease model is helpful to further explore the specific etiology, pathogenesis, complications and prevention and control methods, etc., in order to expand the scope of research, Improving the level of medicine laid a scientific foundation.
【作者单位】：桂林医学院附属医院肾内科;桂林医学院附属医院内分泌科;
【基金】：广西科技计划项目(桂科AD16450020) 桂林市科学研究与技术开发计划项目(20150126-1-1) 广西壮族自治区卫生厅科研课题(Z2014301)
【分类号】：R-332

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