生长抑素联合双氯芬酸钠对胆总管结石ERCP术后胰腺炎的预防作用

发布时间：2018-03-04 22:35

本文选题：胰腺炎　切入点：内镜下逆行胰胆管造影术　出处：《山东医药》2015年04期 　论文类型：期刊论文

【摘要】：目的观察生长抑素联合双氯芬酸钠对胆总管结石内镜下逆行胰胆管造影术(ERCP)术后高淀粉酶血症及胰腺炎的预防作用。方法行胆总管结石ERCP取石患者80例,随机分为实验组和对照组各40例。两组术前均给予镇静、麻醉等常规药物;实验组术前30 min给予双氯芬酸钠50 mg塞肛,生长抑素0.25 mg/h持续泵入,维持24 h。所有患者ERCP术前3 h及术后3、12、24 h检测血清淀粉酶水平,并观察有无急性胰腺炎的临床表现。结果实验组ERCP术后3、12、24 h血清淀粉酶分别为(195.6±101.4)、(353.3±128.5)、(260.6±85.7)U/L,对照组分别为(323.7±180.7)、(495.5±181.1)、(386.9±119.8)U/L,P均0.05。实验组ERCP术后高淀粉酶血症、术后胰腺炎发生率(40%、2.5%)低于对照组(72.5%、15%),P均0.05。结论生长抑素联合双氯芬酸钠可以有效预防ERCP术后高血清淀粉酶血症及术后胰腺炎的发生。
[Abstract]:Objective to observe the preventive effect of somatostatin combined with diclofenac sodium on hyperamylase and pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP) for choledocholithiasis. Two groups were randomly divided into two groups: 40 cases in the experimental group and 40 cases in the control group. The two groups were given routine drugs such as sedation and anaesthesia before operation, and the experimental group was given diclofenac sodium 50 mg to plug the anus 30 min before operation, and somatostatin 0.25 mg/h was continuously pumped in. The serum amylase levels were measured at 3h before ERCP and 312h after ERCP for 24 hours. Results the serum amylase levels in the experimental group were 195.6 卤101.4U / L at 24 h after ERCP, respectively, 260.6 卤85.7 U / L for the control group and 323.7 卤180.7 U / L for the control group, respectively. The incidence of postoperative pancreatitis was lower than that of control group (P < 0.05). Conclusion somatostatin combined with diclofenac sodium can effectively prevent high serum amylase and postoperative pancreatitis after ERCP.
【作者单位】：三峡大学人民医院;
【分类号】：R576

【相似文献】