异羟戊酸复合高渗盐对失血性休克模型大鼠血流动力学的影响

发布时间：2018-03-06 12:41

本文选题：组织工程　切入点：休克　出处：《中国组织工程研究》2015年27期 　论文类型：期刊论文

【摘要】：背景:研究表明异羟戊酸对于失血性休克后动物重要脏器有一定的保护作用,7.5%高渗盐对于失血性休克血流动力学的稳定作用显著。目的:观察异羟戊酸复合7.5%高渗盐对失血性休克大鼠血流动力学的影响。方法:将50只大鼠随机等分为5组:假手术组、休克不复苏组、异羟戊酸组、7.5%高渗盐组和7.5%高渗盐复合异羟戊酸组,除假手术组外其他4组建立失血性休克模型。假手术组麻醉置管后不予失血;休克不复苏组失血不复苏,观察60 min后处死;其他3组在失血60 min后分别在5 min和20 min内经静脉给予异羟戊酸、7.5%高渗盐溶液、异羟戊酸溶于7.5%高渗盐干预。各组经股动脉和右颈总动脉置管实时监测心率、平均动脉压和右室收缩压变化。结果与结论:采取一定的复苏措施3 h后,与异羟戊酸组和7.5%高渗盐组相比,7.5%高渗盐复合异羟戊酸组心率最高(P0.05),复苏后不仅平均动脉压和右室收缩压上升平稳,作用时间持久且波动较小(P0.05)。实验结果证实,7.5%高渗盐复合异羟戊酸干预对于失血性休克后大鼠复苏效果优于传统的高渗盐溶液复苏以及单纯的药物复苏。
[Abstract]:Background: studies have shown that isovaleric acid has a protective effect on important organs after hemorrhagic shock. The effect of 7.5% hyperosmotic salt on hemodynamics of hemorrhagic shock is significant. Objective: to observe the effect of isovaleric acid combined with 7.5% high level on hemodynamics of hemorrhagic shock. Effect of salt infiltration on hemodynamics in rats with hemorrhagic shock methods: 50 rats were randomly divided into 5 groups: sham operation group. Hemorrhagic shock model was established in shock non-resuscitation group, isovaleric acid group with 7.5% hypertonic salt and 7.5% hypertonic salt combined with isopentanoic acid, except sham-operation group, the hemorrhagic shock model was established in the other four groups, the sham operation group did not lose blood after anesthesia tube, and the shock non-resuscitation group lost blood and did not resuscitate. After 60 min, the other three groups were given isovalerate 7.5% hypertonic salt solution intravenously for 5 min and 20 min after 60 min of blood loss, and isovaleric acid dissolved in 7.5% hypertonic salt. The heart rate was monitored in real time through femoral artery and right common carotid artery in each group. Results and conclusion: after 3 h of certain resuscitation, the mean arterial pressure and right ventricular systolic pressure were changed. Compared with isovaleric acid group and 7.5% hypertonic salt group, the heart rate of 7.5% hypertonic salt combined with isovaleric acid group was the highest (P 0.05). After resuscitation, not only the mean arterial pressure and right ventricular systolic pressure increased steadily, but also the right ventricular systolic pressure increased steadily after resuscitation. The results showed that 7.5% hyperosmotic salt combined with isopentanoic acid had better effect on resuscitation of rats after hemorrhagic shock than that of traditional hypertonic salt solution and drug resuscitation.
【作者单位】：兰州大学第二医院;解放军兰州军区总医院麻醉科;
【分类号】：R459.7;R-332

【参考文献】