手术麻醉对分娩时母婴免疫的影响

发布时间：2018-03-07 07:30

本文选题：麻醉　切入点：分娩　出处：《齐齐哈尔医学院学报》2016年18期 　论文类型：期刊论文

【摘要】：目的研究并探讨手术麻醉对分娩时母婴免疫功能的影响。方法 2013年1月至2015年6月我院收治的分娩产妇中,选取100例足月单胎妊娠的产妇对比研究,采取数字抽签法分为对照组、观察组,每组各50例产妇。对照组产妇在手术过程中不采取麻醉镇痛措施,观察组在手术过程中给予硬膜外阻滞麻醉。在分娩时,使用流式细胞仪对产妇的外周血和新生儿的脐带血进行检测。对比两组产妇的VAS疼痛评分,并对比两组产妇分娩过程中各个时间点及新生儿的NK细胞、CD3~+、CD4~+以及CD4~+/CD8~+。结果与对照组相比,观察组产妇的VAS疼痛评分明显更低(P0.05)。两组产妇在分娩过程中各个时间点的NK细胞、CD3~+、CD4~+以及CD4~+/CD8~+均出现一定幅度的下降,但观察组的下降幅度不明显(P0.05),而对照组的下降幅度明显(P0.05)。与对照组相比,观察组新生儿的NK细胞、CD3~+、CD4~+以及CD4~+/CD8~+均明显更高(P0.05)。结论在分娩过程中,给予产妇适当的麻醉镇痛措施,能够有效减轻分娩过程中的疼痛,减轻分娩时的疼痛应激反应对产妇免疫功能和新生儿免疫功能的影响。
[Abstract]:Objective to study the effect of surgical anesthesia on maternal and infant immune function during delivery. Methods from January 2013 to June 2015, 100 pregnant women with single term pregnancy were selected. The control group (n = 50) was divided into control group (n = 50), observation group (n = 50) and control group (n = 50). The control group did not take anesthetic analgesic measures during operation, and the observation group received epidural block anesthesia during operation. Flow cytometry was used to detect the peripheral blood of parturient and umbilical cord blood of newborns. The VAS pain scores of the two groups were compared. The results of NK cell CD3 ~ + CD4 ~ and CD4 ~ / / CD8 ~ + in the two groups were compared with those in the control group. The VAS pain score of the observation group was significantly lower than that of the control group (P 0.05). The NK cell CD3 ~ + CD4 ~ and CD4 ~ / CD8 ~ of the parturient in the two groups decreased to a certain extent at each time point during labor. Compared with the control group, the NK cells of the observation group were significantly higher than those of the control group. Conclusion during labor, the newborn infants in the observation group were given appropriate anesthetic analgesia measures. The results showed that the NK cells of the neonates in the observation group were significantly higher than those in the control group, and that the levels of CD 4 and CD 4 / CD 8 were significantly higher in the observation group than in the control group, and the decrease was not significant in the observation group, but the decrease in the control group was significantly higher than that in the control group. It can effectively relieve the pain during delivery and the effect of pain stress on maternal immune function and neonatal immune function.
【作者单位】：广东开平市妇幼保健院麻醉科;深圳市宝安区妇幼保健院麻醉科;
【分类号】：R614

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