右美托咪定复合丙泊酚用于无痛纤维结肠镜检查的临床疗效及安全性评价

发布时间：2018-03-10 00:39

本文选题：纤维结肠镜　切入点：无痛　出处：《中国临床药理学杂志》2015年10期 　论文类型：期刊论文

【摘要】：目的评价右美托咪定复合丙泊酚用于无痛纤维结肠镜检查术的临床疗效及安全性。方法将48例拟进行纤维结肠镜检查的患者随机分为试验组22例和对照组26例。对照组静脉注射丙泊酚2.5 mg·kg-1,术中根据患者麻醉情况追加0.5~1.0 mg·kg-1。试验组首先缓慢静脉推注(10 min)右美托咪定1μg·kg-1,然后静脉注射丙泊酚2 mg·kg-1。2组患者麻醉后置入纤维结肠镜,并寻腔进镜对患者肠腔内壁进行检查。检查过程中分析比较2组患者的镇痛效果、起效时间、苏醒时间、离院时间及麻醉过程中的不良反应发生率有无差别。结果试验组镇痛效果明显优于对照组(P0.05)。试验组起效时间、苏醒时间及离院时间均明显短于对照组,丙泊酚用量小于对照组(均P0.05)。试验组头晕及躁动发生率显著低于对照组(均P0.05),而恶心呕吐、舌后坠及呼吸抑制发生率比较差异均无统计学意义(P0.05)。结论右美托咪定复合丙泊酚用于无痛纤维结肠镜检查镇痛效果好,不良反应发生率低。
[Abstract]:Objective to evaluate the clinical efficacy and safety of dexmetomidine combined with propofol in painless fibercolonoscopy. Methods 48 patients were randomly divided into trial group (n = 22) and control group (n = 26). In the control group, propofol 2.5 mg 路kg -1 was injected intravenously, and 0.5 mg 路kg -1 was added during the operation according to the anesthetic condition of the patients. In the trial group, 1 渭 g 路kg -1 dexmetomidine was injected slowly for 10 minutes. Then the patients in the 2 mg 路kg-1.2 group received intravenous injection of propofol were treated with fibrocolonoscopy after anesthesia. During the examination, the analgesic effect, the effective time and the recovery time of the two groups were analyzed and compared. Results the analgesic effect of the experimental group was significantly better than that of the control group (P 0.05). The onset time, recovery time and absence time of the experimental group were significantly shorter than that of the control group. The dosage of propofol was lower than that of the control group (all P 0.05). The incidence of dizziness and restlessness in the trial group was significantly lower than that in the control group (all P 0.05), but nausea and vomiting. There was no significant difference in the incidence of retrolingual locus and respiratory depression. Conclusion dexmetomidine combined with propofol has good analgesic effect and low incidence of adverse reactions in painless fibercolonoscopy.
【作者单位】：衢州市人民医院普外科;
【基金】：浙江衢州市科技基金资助项目(2014P022)
【分类号】：R614

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