右美托咪定对罗库溴铵肌松作用的影响

发布时间：2018-03-10 03:31

本文选题：全凭静脉麻醉　切入点：右美托咪定　出处：《石河子大学》2014年硕士论文　论文类型：学位论文

【摘要】：目的:观察全凭静脉麻醉下预注右美托咪定对罗库溴铵起效时间和作用时间的影响。方法:选取自2012年12月至2013年5月在中国人民解放军海军总医院耳鼻喉科收治的60例全凭静脉麻醉下行鼻内窥镜手术的患者为研究对象，随机分为右美托咪定组30例和对照组30例。右美托咪定组于麻醉诱导前15min静脉泵入1.0μg/kg的右美托咪定（10min内泵注完毕），对照组于麻醉诱导前静脉泵入0.9%氯化钠注射液。分别记录两组患者麻醉诱导给药前、给药后、气管插管前、插管后1min、3min、5min的平均动脉压（MAP），心率（HR），脉搏-氧饱和度（SpO2）值，，记录罗库溴铵的起效时间和25%的恢复时间、50%的恢复时间、75%的恢复时间、90%的恢复时间。结果:右美托咪定组与对照组相比较罗库溴铵的起效时间缩短（P0.05），两组比较25%的恢复时间、50%的恢复时间、75%的恢复时间、90%的恢复时间的差异无统计学意义（P0.05）。结论:麻醉诱导前预注右美托咪定可以缩短罗库溴铵的起效时间，但对罗库溴铵的作用时间没有影响。
[Abstract]:Aim: to observe the effect of dexmetomidine on the onset time and action time of rocuronium bromide under total intravenous anesthesia. Methods: from December 2012 to May 2013, 60 patients with nasal endoscopy were treated in the Department of Otorhinolaryngology, Naval General Hospital of the Chinese people's Liberation Army (PLA) from December 2012 to May 2013. The dexmetomidine group (n = 30) and the control group (n = 30) were randomly divided into two groups: dexmetomidine group (n = 30) received intravenous injection of 1.0 渭 g / kg dexmetomidine within 10 minutes before anesthesia induction, and control group (n = 30) received 0.9% sodium chloride injection before anesthesia induction. Before anesthesia induction, two groups of patients were recorded. The mean arterial pressure (MAPP), heart rate (HRV) and pulse oxygen saturation (SPO _ 2) were measured before and 1 min after endotracheal intubation. The onset time of rocuronium and the recovery time of 25% were recorded. The recovery time of rocuronium and 25% was 75% and 90% respectively. Results: the onset time of rocuronium bromide in dexmetomidine group was shorter than that in control group (P 0.05). There was no significant difference between the two groups in 25% recovery time (50%) and 90% (90%) recovery time (P 0.05). Conclusion: preinjection of dexmetomidine before anesthesia induction can shorten the onset time of rocuronium bromide, but has no effect on rocuronium action time.
【学位授予单位】：石河子大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R614

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