全麻患者麻醉术后下呼吸道感染病原菌分布及对机体血小板活化因子和干扰素γ的调控作用

发布时间：2018-03-11 06:07

本文选题：全身麻醉　切入点：病原菌分布　出处：《实用临床医药杂志》2016年11期 　论文类型：期刊论文

【摘要】：目的探讨全麻患者麻醉术后下呼吸道感染的病原菌分布及对患者血小板活化因子(PAF)及干扰素γ(IFN-γ)水平的影响。方法将90例全麻麻醉术后下呼吸道感染患者设为感染组,同期健康体检者90例设为对照组,全麻麻醉术后未感染患者90例设为未感染组。采用全自动微生物鉴定仪对病原菌鉴定,检测3组PAF、组织性纤溶酶原激活物(T-PA)、前列腺素E2(PEG2)、单核细胞趋化因子1(MCP-1)及IFN-γ、转化生长因子β(TGF-β)、肿瘤坏死因子α(TNF-α)和肿瘤坏死因子相关凋亡诱导配体(TRAIL)水平。结果感染患者共分离病原菌90株,包括革兰阳性菌43株和革兰阴性菌47株。感染患者血清中PEG2、MCP-1和IFN-γ、TGF-β、TNF-α水平显著升高(P0.05),而PAF、T-PA和TRAL水平显著降低(P0.05),且与对照组和未感染组相比差异有统计学意义(P0.05或P0.01)。结论全麻患者麻醉术后容易并发下呼吸道感染,且感染引起PAF水平降低和INF-γ水平明显升高。
[Abstract]:Objective to investigate the distribution of pathogenic bacteria in patients with lower respiratory tract infection after general anesthesia and its effect on the levels of platelet activating factor PAF and interferon 纬 IFN- 纬. Methods 90 patients with lower respiratory tract infection after general anesthesia were divided into infection group. At the same time, 90 healthy persons were set up as control group, 90 cases of uninfected patients after general anesthesia were selected as uninfected group, and the pathogen was identified by automatic microbiological identification instrument. The levels of PAF, tissue plasminogen activator (TPA), prostaglandin E 2 (PEG 2), monocyte chemokine (1 MCP 1) and IFN- 纬, transforming growth factor 尾 -TGF- 尾, tumor necrosis factor- 伪 (TNF- 伪) and tumor necrosis factor-related apoptosis-inducing ligand (TRAILL) were measured in three groups. 90 strains of pathogenic bacteria were isolated. The serum levels of PEG2MCP-1 and IFN- 纬 TGF- 尾 TNF- 伪 in infected patients were significantly increased, while the levels of PAFT-PA and TRAL were significantly lower than those of control group and uninfected group (P0.05 or P0.01a, respectively), including 43 Gram-positive bacteria and 47 Gram-negative bacilli. The serum levels of PEG2MP-1 and IFN- 纬 -TGF- 尾 TNF- 伪 were significantly higher than those of control group and uninfected group. Lower respiratory tract infection is easy to occur in patients with general anesthesia after anaesthesia. The PAF level was decreased and the INF- 纬 level was significantly increased after infection.
【作者单位】：湖北省襄阳市中心医院麻醉科;
【分类号】：R614.2

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