右美托咪定对宫腹腔镜手术患者镇痛疗效与安全性的研究

发布时间：2018-03-12 08:31

本文选题：右美托咪定　切入点：宫腹腔镜联合手术　出处：《中国临床药理学杂志》2015年02期 　论文类型：期刊论文

【摘要】：目的评价右美托咪定在宫腹腔镜联合手术患者的镇痛疗效与安全性。方法 90例行宫腹腔镜联合手术的患者随机分为3组:对照组(C组)、右美托咪定1组(D1组)和2组(D2组)。D1、D2组,麻醉诱导后10 min,静脉泵入右美托咪定0.4μg·kg-1;C组给等量0.9%Na Cl溶液。记录围术期循环指标、脑电双频谱指数(BIS)、手术时间、拔管时间,用视觉模拟评分法(VAS)评估手术后2,4,12,24 h的疼痛程度,并记录不良反应及镇痛药物使用情况。结果 D1、D2组循环指标较C组稳定,BIS值低于C组。D1组拔管时间长于C组,D2组拔管时间与C组差异无统计学意义。D1、D2组患者VAS低于C组,不良反应少,使用镇痛药物例数少。结论宫腹腔镜联合手术患者静脉泵注右美托咪定0.4μg·kg-1可节俭麻醉维持药物,不延长拔管时间,减轻术后疼痛,降低不良反应发生率,减少术后镇痛药物的用量。
[Abstract]:Objective to evaluate the analgesic efficacy and safety of dexmetomidine in patients undergoing combined hysteroscopy and laparoscopy. Methods 90 patients undergoing combined laparoscopic surgery were randomly divided into three groups: control group C, dexmetomidine group D 1). And group 2, group D 2, group D 1, group D 2, Ten minutes after anesthesia induction, intravenous infusion of dexmetomidine 0.4 渭 g 路kg ~ (-1) group was given an equal amount of 0.9 NaCl solution. The perioperative circulatory index, bispectral index (BISI), operation time and extubation time were recorded. Visual analogue score (VAS-VASA) was used to evaluate the pain level of 2h 41224 h after operation. Results the circulatory index of D1D _ 2 group was lower than that of C group. The extubation time of D _ 1 D _ 2 group was longer than that of C group. The VAS of D _ 1 D _ 2 group was lower than that of C group, and that of D _ 1 D _ 2 group was lower than that of C group. Conclusion intravenous infusion of dexmetomidine 0.4 渭 g 路kg-1 by intravenous pump in patients undergoing hysteroscopy combined with laparoscopic surgery can save anesthesia and maintain the drug without prolonging the extubation time, alleviating postoperative pain and reducing the incidence of adverse reactions. Reduce postoperative analgesic dosage.
【作者单位】：北京大学第三医院麻醉科;北京大学第三医院生殖医学中心;
【分类号】：R614

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